E3 ubiquitin-protein ligase TRIM63 (EC 2.3.2.27) (Iris RING finger protein) (Muscle-specific RING finger protein 1) (MuRF-1) (MuRF1) (RING finger protein 28) (RING-type E3 ubiquitin transferase TRIM63) (Striated muscle RING zinc finger protein) (Tripartite motif-containing protein 63)
1_MDYKS 6_ SLIQD 11_ GNPME 16_ NLEKQ 21_ LICPI 26_ CLEMF 31_ TKPVV 36_ ILPCQ 41_ HNLCR 46_ KCAND 51_ IFQAA 56_ NPYWT 61_ SRGSS 66_ VSMSG 71_ GRFRC 76_ PTCRH 81_ EVIMD 86_ RHGVY 91_ GLQRN 96_ LLVEN 101_ IIDIY 106_ KQECS 111_ SRPLQ 116_ KGSHP 121_ MCKEH 126_ EDEKI 131_ NIYCL 136_ TCEVP 141_ TCSMC 146_ KVFGI 151_ HKACE 156_ VAPLQ 161_ SVFQG 166_ QKTEL 171_ NNCIS 176_ MLVAG 181_ NDRVQ 186_ TIITQ 191_ LEDSR 196_ RVTKE 201_ NSHQV 206_ KEELS 211_ QKFDT 216_ LYAIL 221_ DEKKS 226_ ELLQR 231_ ITQEQ 236_ EKKLS 241_ FIEAL 246_ IQQYQ 251_ EQLDK 256_ STKLV 261_ ETAIQ 266_ SLDEP 271_ GGATF 276_ LLTAK 281_ QLIKS 286_ IVEAS 291_ KGCQL 296_ GKTEQ 301_ GFENM 306_ DFFTL 311_ DLEHI 316_ ADALR 321_ AIDFG 326_ TDEEE 331_ EEFIE 336_ EEDQE 341_ EEEST 346_EGKEE
1: E3 ubiquitin ligase. Mediates the ubiquitination and subsequent proteasomal degradation of CKM, GMEB1 and HIBADH. Regulates the proteasomal degradation of muscle proteins under amino acid starvation, where muscle protein is catabolized to provide other organs with amino acids. Inhibits de novo skeletal muscle protein synthesis under amino acid starvation. Regulates proteasomal degradation of cardiac troponin I/TNNI3 and probably of other sarcomeric-associated proteins. May play a role in striated muscle atrophy and hypertrophy by regulating an anti-hypertrophic PKC-mediated signaling pathway. May regulate the organization of myofibrils through TTN in muscle cells