Ras-related protein Rab-24
1_MSGQR 6_ VDVKV 11_ VMLGK 16_ EYVGK 21_ TSLVE 26_ RYVHD 31_ RFLVG 36_ PYQNT 41_ IGAAF 46_ VAKVM 51_ SVGDR 56_ TVTLG 61_ IWDTA 66_ GSERY 71_ EAMSR 76_ IYYRG 81_ AKAAI 86_ VCYDL 91_ TDSSS 96_ FERAK 101_ FWVKE 106_ LRSLE 111_ EGCQI 116_ YLCGT 121_ KSDLL 126_ EEDRR 131_ RRRVD 136_ FHDVQ 141_ DYADN 146_ IKAQL 151_ FETSS 156_ KTGQS 161_ VDELF 166_ QKVAE 171_ DYVSV 176_ AAFQV 181_ MTEDK 186_ GVDLG 191_ QKPNP 196_YFYSC
1: The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes. Rabs cycle between an inactive GDP-bound form and an active GTP-bound form that is able to recruit to membranes different sets of downstream effectors directly responsible for vesicle formation, movement, tethering and fusion. RAB24 is an atypical RAB protein that presents low GTPase activity and thereby exists predominantly in the GTP-bound active state. RAB24 is required for the clearance of late autophagic vacuoles under basal conditions. It is not needed for starvation-induced autophagy. Involved in the modulation of meiotic apparatus assembly and meiotic progression during oocyte maturation, possibly through regulation of kinetochore-microtubule interaction