Endonuclease 8-like 2 (EC 3.2.2.-) (EC 4.2.99.18) (DNA glycosylase/AP lyase Neil2) (DNA-(apurinic or apyrimidinic site) lyase Neil2) (Endonuclease VIII-like 2) (Nei homolog 2) (NEH2) (Nei-like protein 2)
1_MPEGP 6_ LVRKF 11_ HHLVS 16_ PFVGQ 21_ QVVKT 26_ GGSSK 31_ KLQPA 36_ SLQSL 41_ WLQDT 46_ QVHGK 51_ KLFLR 56_ FDLDE 61_ EMGPP 66_ GSSPT 71_ PEPPQ 76_ KEVQK 81_ EGAAD 86_ PKQVG 91_ EPSGQ 96_ KTLDG 101_ SSRSA 106_ ELVPQ 111_ GEDDS 116_ EYLER 121_ DAPAG 126_ DAGRW 131_ LRVSF 136_ GLFGS 141_ VWVND 146_ FSRAK 151_ KANKR 156_ GDWRD 161_ PSPRL 166_ VLHFG 171_ GGGFL 176_ AFYNC 181_ QLSWS 186_ SSPVV 191_ TPTCD 196_ ILSEK 201_ FHRGQ 206_ ALEAL 211_ GQAQP 216_ VCYTL 221_ LDQRY 226_ FSGLG 231_ NIIKN 236_ EALYR 241_ AGIHP 246_ LSLGS 251_ VLSAS 256_ RREVL 261_ VDHVV 266_ EFSTA 271_ WLQGK 276_ FQGRP 281_ QHTQV 286_ YQKEQ 291_ CPAGH 296_ QVMKE 301_ AFGPE 306_ DGLQR 311_ LTWWC 316_ PQCQP 321_ QLSEE 326_PEQCQ
1: Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Has DNA glycosylase activity towards 5-hydroxyuracil and other oxidized derivatives of cytosine with a preference for mismatched double-stranded DNA (DNA bubbles). Has low or no DNA glycosylase activity towards thymine glycol, 2-hydroxyadenine, hypoxanthine and 8-oxoguanine. Has AP (apurinic/apyrimidinic) lyase activity and introduces nicks in the DNA strand. Cleaves the DNA backbone by beta-delta elimination to generate a single-strand break at the site of the removed base with both 3'- and 5'-phosphates