Polyamine deacetylase HDAC10 (EC 3.5.1.48) (EC 3.5.1.62) (Histone deacetylase 10) (HD10)
1_MGTAL 6_ VYHED 11_ MTATR 16_ LLWDD 21_ PECEI 26_ ERPER 31_ LTAAL 36_ DRLRQ 41_ RGLEQ 46_ RCLRL 51_ SAREA 56_ SEEEL 61_ GLVHS 66_ PEYVS 71_ LVRET 76_ QVLGK 81_ EELQA 86_ LSGQF 91_ DAIYF 96_ HPSTF 101_ HCARL 106_ AAGAG 111_ LQLVD 116_ AVLTG 121_ AVQNG 126_ LALVR 131_ PPGHH 136_ GQRAA 141_ ANGFC 146_ VFNNV 151_ AIAAA 156_ HAKQK 161_ HGLHR 166_ ILVVD 171_ WDVHH 176_ GQGIQ 181_ YLFED 186_ DPSVL 191_ YFSWH 196_ RYEHG 201_ RFWPF 206_ LRESD 211_ ADAVG 216_ RGQGL 221_ GFTVN 226_ LPWNQ 231_ VGMGN 236_ ADYVA 241_ AFLHL 246_ LLPLA 251_ FEFDP 256_ ELVLV 261_ SAGFD 266_ SAIGD 271_ PEGQM 276_ QATPE 281_ CFAHL 286_ TQLLQ 291_ VLAGG 296_ RVCAV 301_ LEGGY 306_ HLESL 311_ AESVC 316_ MTVQT 321_ LLGDP 326_ APPLS 331_ GPMAP 336_ CQSAL 341_ ESIQS 346_ ARAAQ 351_ APHWK 356_ SLQQQ 361_ DVTAV 366_ PMSPS 371_ SHSPE 376_ GRPPP 381_ LLPGG 386_ PVCKA 391_ AASAP 396_ SSLLD 401_ QPCLC 406_ PAPSV 411_ RTAVA 416_ LTTPD 421_ ITLVL 426_ PPDVI 431_ QQEAS 436_ ALREE 441_ TEAWA 446_ RPHES 451_ LAREE 456_ ALTAL 461_ GKLLY 466_ LLDGM 471_ LDGQV 476_ NSGIA 481_ ATPAS 486_ AAAAT 491_ LDVAV 496_ RRGLS 501_ HGAQR 506_ LLCVA 511_ LGQLD 516_ RPPDL 521_ AHDGR 526_ SLWLN 531_ IRGKE 536_ AAALS 541_ MFHVS 546_ TPLPV 551_ MTGGF 556_ LSCIL 561_ GLVLP 566_ LAYGF 571_ QPDLV 576_ LVALG 581_ PGHGL 586_ QGPHA 591_ ALLAA 596_ MLRGL 601_ AGGRV 606_ LALLE 611_ ENSTP 616_ QLAGI 621_ LARVL 626_ NGEAP 631_ PSLGP 636_ SSVAS 641_ PEDVQ 646_ ALMYL 651_ RGQLE 656_ PQWKM 661_LQCHP
1: Polyamine deacetylase (PDAC), which acts preferentially on N(8)-acetylspermidine, and also on acetylcadaverine and acetylputrescine (PubMed:28516954). Exhibits attenuated catalytic activity toward N(1),N(8)-diacetylspermidine and very low activity, if any, toward N(1)-acetylspermidine (PubMed:28516954). Histone deacetylase activity has been observed in vitro (PubMed:11677242, PubMed:11726666, PubMed:11739383, PubMed:11861901). Has also been shown to be involved in MSH2 deacetylation (PubMed:26221039). The physiological relevance of protein/histone deacetylase activity is unclear and could be very weak (PubMed:28516954). May play a role in the promotion of late stages of autophagy, possibly autophagosome-lysosome fusion and/or lysosomal exocytosis in neuroblastoma cells (PubMed:23801752, PubMed:29968769). May play a role in homologous recombination (PubMed:21247901). May promote DNA mismatch repair (PubMed:26221039)