Ubiquitin-conjugating enzyme E2 E3 (EC 2.3.2.23) (E2 ubiquitin-conjugating enzyme E3) (UbcH9) (Ubiquitin carrier protein E3) (Ubiquitin-conjugating enzyme E2-23 kDa) (Ubiquitin-protein ligase E3)
1_MSSDR 6_ QRSDD 11_ ESPST 16_ SSGSS 21_ DADQR 26_ DPAAP 31_ EPEEQ 36_ EERKP 41_ SATQQ 46_ KKNTK 51_ LSSKT 56_ TAKLS 61_ TSAKR 66_ IQKEL 71_ AEITL 76_ DPPPN 81_ CSAGP 86_ KGDNI 91_ YEWRS 96_ TILGP 101_ PGSVY 106_ EGGVF 111_ FLDIT 116_ FSSDY 121_ PFKPP 126_ KVTFR 131_ TRIYH 136_ CNINS 141_ QGVIC 146_ LDILK 151_ DNWSP 156_ ALTIS 161_ KVLLS 166_ ICSLL 171_ TDCNP 176_ ADPLV 181_ GSIAT 186_ QYLTN 191_ RAEHD 196_ RIARQ 201_WTKRY
1: Accepts ubiquitin from the E1 complex and catalyzes its covalent attachment to other proteins. In vitro catalyzes 'Lys-11'- and 'Lys-48'-, as well as 'Lys-63'-linked polyubiquitination. Participates in the regulation of transepithelial sodium transport in renal cells