F-box/WD repeat-containing protein 5 (F-box and WD-40 domain-containing protein 5)
1_MDEGG 6_ TPLLP 11_ DSLVY 16_ QIFLS 21_ LGPAD 26_ VLAAG 31_ LVCRQ 36_ WQAVS 41_ RDEFL 46_ WREQF 51_ YRYYQ 56_ VARDV 61_ PRHPA 66_ AMSWY 71_ EEFQR 76_ LYDTV 81_ PCVEV 86_ QTLRE 91_ HTDQV 96_ LHLSF 101_ SHSGY 106_ QFASC 111_ SKDCT 116_ VKIWS 121_ NDLTI 126_ SLLHS 131_ ADMRP 136_ YNWSY 141_ TQFSQ 146_ FNKDD 151_ SLLLA 156_ SGVFL 161_ GPHNS 166_ SSGEI 171_ AVISL 176_ DSFAL 181_ LSRVR 186_ NKPYD 191_ VFGCW 196_ LTETS 201_ LISGN 206_ LHRIG 211_ DITSC 216_ SVLWL 221_ NNAFQ 226_ DVESE 231_ NVNVV 236_ KRLFK 241_ IQNLN 246_ ASTVR 251_ TVMVA 256_ DCSRF 261_ DSPDL 266_ LLEAG 271_ DPATS 276_ PCRIF 281_ DLGSD 286_ NEEVV 291_ AGPAP 296_ AHAKE 301_ GLRHF 306_ LDRVL 311_ EGRAQ 316_ PQLSE 321_ RMLET 326_ KVAEL 331_ LAQGH 336_ TKPPE 341_ RSATG 346_ AKSKY 351_ LIFTT 356_ GCLTY 361_ SPHQI 366_ GIKQI 371_ LPHQM 376_ TTAGP 381_ VLGEG 386_ RGSDA 391_ FFDAL 396_ DHVID 401_ IHGHI 406_ IGMGL 411_ SPDNR 416_ YLYVN 421_ SRAWP 426_ NGAVV 431_ ADPMQ 436_ PPPIA 441_ EEIDL 446_ LVFDL 451_ KTMRE 456_ VRRAL 461_ RAHRA 466_ YTPND 471_ ECFFI 476_ FLDVS 481_ RDFVA 486_ SGAED 491_ RHGYI 496_ WDRHY 501_ NICLA 506_ RLRHE 511_ DVVNS 516_ VVFSP 521_ QEQEL 526_ LLTAS 531_ DDATI 536_ KAWRS 541_ PRTMR 546_ VLQAP 551_ RPRPR 556_ TFFSW 561_LASQR
1: Substrate recognition component of both SCF (SKP1-CUL1-F-box protein) and DCX (DDB1-CUL4-X-box) E3 ubiquitin-protein ligase complexes. Substrate recognition component of the SCF(FBXW5) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of SASS6 during S phase, leading to prevent centriole reduplication. The SCF(FBXW5) complex also mediates ubiquitination and degradation of actin-regulator EPS8 during G2 phase, leading to the transient degradation of EPS8 and subsequent cell shape changes required to allow mitotic progression. Substrate-specific adapter of the DCX(FBXW5) E3 ubiquitin-protein ligase complex which mediates the polyubiquitination and subsequent degradation of TSC2. May also act as a negative regulator of MAP3K7/TAK1 signaling in the interleukin-1B (IL1B) signaling pathway