Nicalin (Nicastrin-like protein)
1_MLEEA 6_ GEVLE 11_ NMLKA 16_ SCLPL 21_ GFIVF 26_ LPAVL 31_ LLVAP 36_ PLPAA 41_ DAAHE 46_ FTVYR 51_ MQQYD 56_ LQGQP 61_ YGTRN 66_ AVLNT 71_ EARTM 76_ AAEVL 81_ SRRCV 86_ LMRLL 91_ DFSYE 96_ QYQKA 101_ LRQSA 106_ GAVVI 111_ ILPRA 116_ MAAVP 121_ QDVVR 126_ QFMEI 131_ EPEML 136_ AMETA 141_ VPVYF 146_ AVEDE 151_ ALLSI 156_ YKQTQ 161_ AASAS 166_ QGSAS 171_ AAEVL 176_ LRTAT 181_ ANGFQ 186_ MVTSG 191_ VQSKA 196_ VSDWL 201_ IASVE 206_ GRLTG 211_ LGGED 216_ LPTIV 221_ IVAHY 226_ DAFGV 231_ APWLS 236_ LGADS 241_ NGSGV 246_ SVLLE 251_ LARLF 256_ SRLYT 261_ YKRTH 266_ AAYNL 271_ LFFAS 276_ GGGKF 281_ NYQGT 286_ KRWLE 291_ DNLDH 296_ TDSSL 301_ LQDNV 306_ AFVLC 311_ LDTVG 316_ RGSSL 321_ HLHVS 326_ KPPRE 331_ GTLQH 336_ AFLRE 341_ LETVA 346_ AHQFP 351_ EVRFS 356_ MVHKR 361_ INLAE 366_ DVLAW 371_ EHERF 376_ AIRRL 381_ PAFTL 386_ SHLES 391_ HRDGQ 396_ RSSIM 401_ DVRSR 406_ VDSKT 411_ LTRNT 416_ RIIAE 421_ ALTRV 426_ IYNLT 431_ EKGTP 436_ PDMPV 441_ FTEQM 446_ QIQQE 451_ QLDSV 456_ MDWLT 461_ NQPRA 466_ AQLVD 471_ KDSTF 476_ LSTLE 481_ HHLSR 486_ YLKDV 491_ KQHHV 496_ KADKR 501_ DPEFV 506_ FYDQL 511_ KQVMN 516_ AYRVK 521_ PAVFD 526_ LLLAV 531_ GIAAY 536_ LGMAY 541_ VAVQH 546_ FSLLY 551_ KTVQR 556_LLVKA
1: Component of the multi-pass translocon (MPT) complex that mediates insertion of multi-pass membrane proteins into the lipid bilayer of membranes (PubMed:32820719, PubMed:36261522). The MPT complex takes over after the SEC61 complex: following membrane insertion of the first few transmembrane segments of proteins by the SEC61 complex, the MPT complex occludes the lateral gate of the SEC61 complex to promote insertion of subsequent transmembrane regions (PubMed:36261522). May antagonize Nodal signaling and subsequent organization of axial structures during mesodermal patterning, via its interaction with NOMO (By similarity)