Myocardin-related transcription factor A (MRTF-A) (MKL/myocardin-like protein 1) (Megakaryoblastic leukemia 1 protein) (Megakaryocytic acute leukemia protein)
1_MPPLK 6_ SPAAF 11_ HEQRR 16_ SLERA 21_ RTEDY 26_ LKRKI 31_ RSRPE 36_ RSELV 41_ RMHIL 46_ EETSA 51_ EPSLQ 56_ AKQLK 61_ LKRAR 66_ LADDL 71_ NEKIA 76_ QRPGP 81_ MELVE 86_ KNILP 91_ VESSL 96_ KEAII 101_ VGQVN 106_ YPKVA 111_ DSSSF 116_ DEDSS 121_ DALSP 126_ EQPAS 131_ HESQG 136_ SVPSP 141_ LEARV 146_ SEPLL 151_ SATSA 156_ SPTQV 161_ VSQLP 166_ MGRDS 171_ REMLF 176_ LAEQP 181_ PLPPP 186_ PLLPP 191_ SLTNG 196_ TTIPT 201_ AKSTP 206_ TLIKQ 211_ SQPKS 216_ ASEKS 221_ QRSKK 226_ AKELK 231_ PKVKK 236_ LKYHQ 241_ YIPPD 246_ QKQDR 251_ GAPPM 256_ DSSYA 261_ KILQQ 266_ QQLFL 271_ QLQIL 276_ NQQQQ 281_ QHHNY 286_ QAILP 291_ APPKS 296_ AGEAL 301_ GSSGT 306_ PPVRS 311_ LSTTN 316_ SSSSS 321_ GAPGP 326_ CGLAR 331_ QNSTS 336_ LTGKP 341_ GALPA 346_ NLDDM 351_ KVAEL 356_ KQELK 361_ LRSLP 366_ VSGTK 371_ TELIE 376_ RLRAY 381_ QDQIS 386_ PVPGA 391_ PKAPA 396_ ATSIL 401_ HKAGE 406_ VVVAF 411_ PAARL 416_ STGPA 421_ LVAAG 426_ LAPAE 431_ VVVAT 436_ VASSG 441_ VVKFG 446_ STGST 451_ PPVSP 456_ TPSER 461_ SLLST 466_ GDENS 471_ TPGDT 476_ FGEMV 481_ TSPLT 486_ QLTLQ 491_ ASPLQ 496_ ILVKE 501_ EGPRA 506_ GSCCL 511_ SPGGR 516_ AELEG 521_ RDKDQ 526_ MLQEK 531_ DKQIE 536_ ALTRM 541_ LRQKQ 546_ QLVER 551_ LKLQL 556_ EQEKR 561_ AQQPA 566_ PAPAP 571_ LGTPV 576_ KQENS 581_ FSSCQ 586_ LSQQP 591_ LGPAH 596_ PFNPS 601_ LAAPA 606_ TNHID 611_ PCAVA 616_ PGPPS 621_ VVVKQ 626_ EALQP 631_ EPEPV 636_ PAPQL 641_ LLGPQ 646_ GPSLI 651_ KGVAP 656_ PTLIT 661_ DSTGT 666_ HLVLT 671_ VTNKN 676_ ADSPG 681_ LSSGS 686_ PQQPS 691_ SQPGS 696_ PAPAP 701_ SAQMD 706_ LEHPL 711_ QPLFG 716_ TPTSL 721_ LKKEP 726_ PGYEE 731_ AMSQQ 736_ PKQQE 741_ NGSSS 746_ QQMDD 751_ LFDIL 756_ IQSGE 761_ ISADF 766_ KEPPS 771_ LPGKE 776_ KPSPK 781_ TVCGS 786_ PLAAQ 791_ PSPSA 796_ ELPQA 801_ APPPP 806_ GSPSL 811_ PGRLE 816_ DFLES 821_ STGLP 826_ LLTSG 831_ HDGPE 836_ PLSLI 841_ DDLHS 846_ QMLSS 851_ TAILD 856_ HPPSP 861_ MDTSE 866_ LHFVP 871_ EPSST 876_ MGLDL 881_ ADGHL 886_ DSMDW 891_ LELSS 896_ GGPVL 901_ SLAPL 906_ STTAP 911_ SLFST 916_ DFLDG 921_ HDLQL 926_HWDSC
1: Transcription coactivator that associates with the serum response factor (SRF) transcription factor to control expression of genes regulating the cytoskeleton during development, morphogenesis and cell migration (PubMed:26224645). The SRF-MRTFA complex activity responds to Rho GTPase-induced changes in cellular globular actin (G-actin) concentration, thereby coupling cytoskeletal gene expression to cytoskeletal dynamics. MRTFA binds G-actin via its RPEL repeats, regulating activity of the MRTFA-SRF complex. Activity is also regulated by filamentous actin (F-actin) in the nucleus