Alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 6 (EC 2.4.99.-) (GalNAc alpha-2,6-sialyltransferase VI) (ST6GalNAc VI) (ST6GalNAcVI) (hST6GalNAc VI) (Sialyltransferase 7F) (SIAT7-F)
1_MACSR 6_ PPSQC 11_ EPTSL 16_ PPGPP 21_ AGRRH 26_ LPLSR 31_ RRREM 36_ SSNKE 41_ QRSAV 46_ FVILF 51_ ALITI 56_ LILYS 61_ SNSAN 66_ EVFHY 71_ GSLRG 76_ RSRRP 81_ VNLKK 86_ WSITD 91_ GYVPI 96_ LGNKT 101_ LPSRC 106_ HQCVI 111_ VSSSS 116_ HLLGT 121_ KLGPE 126_ IERAE 131_ CTIRM 136_ NDAPT 141_ TGYSA 146_ DVGNK 151_ TTYRV 156_ VAHSS 161_ VFRVL 166_ RRPQE 171_ FVNRT 176_ PETVF 181_ IFWGP 186_ PSKMQ 191_ KPQGS 196_ LVRVI 201_ QRAGL 206_ VFPNM 211_ EAYAV 216_ SPGRM 221_ RQFDD 226_ LFRGE 231_ TGKDR 236_ EKSHS 241_ WLSTG 246_ WFTMV 251_ IAVEL 256_ CDHVH 261_ VYGMV 266_ PPNYC 271_ SQRPR 276_ LQRMP 281_ YHYYE 286_ PKGPD 291_ ECVTY 296_ IQNEH 301_ SRKGN 306_ HHRFI 311_ TEKRV 316_ FSSWA 321_ QLYGI 326_TFSHP
1: Transfers the sialyl group (N-acetyl-alpha-neuraminyl or NeuAc) from CMP-NeuAc onto glycoproteins and glycolipids, forming an alpha-2,6-linkage. Produces branched type disialyl structures by transfer of a sialyl group onto the GalNAc or GlcNAc residue inside backbone core chains having a terminal sialic acid with an alpha-2,3-linkage on Gal. ST6GalNAcVI prefers glycolipids to glycoproteins, predominantly catalyzing the biosynthesis of ganglioside GD1alpha from GM1b (PubMed:12668675, PubMed:17123352). Besides GMb1, MSGG and other glycolipids, it shows activity towards sialyl Lc4Cer generating disialyl Lc4Cer, which can lead to the synthesis of disialyl Lewis a (Le(a)), suggested to be a cancer-associated antigen (PubMed:12668675). Also has activity toward GD1a and GT1b, and can generate DSGG (disialylgalactosylgloboside) from MSGG (monosialylgalactosylgloboside) (By similarity)