U3 small nucleolar RNA-associated protein 4 homolog (Cirhin) (UTP4 small subunit processome component)
1_MGEFK 6_ VHRVR 11_ FFNYV 16_ PSGIR 21_ CVAYN 26_ NQSNR 31_ LAVSR 36_ TDGTV 41_ EIYNL 46_ SANYF 51_ QEKFF 56_ PGHES 61_ RATEA 66_ LCWAE 71_ GQRLF 76_ SAGLN 81_ GEIME 86_ YDLQA 91_ LNIKY 96_ AMDAF 101_ GGPIW 106_ SMAAS 111_ PSGSQ 116_ LLVGC 121_ EDGSV 126_ KLFQI 131_ TPDKI 136_ QFERN 141_ FDRQK 146_ SRILS 151_ LSWHP 156_ SGTHI 161_ AAGSI 166_ DYISV 171_ FDVKS 176_ GSAVH 181_ KMIVD 186_ RQYMG 191_ VSKRK 196_ CIVWG 201_ VAFLS 206_ DGTII 211_ SVDSA 216_ GKVQF 221_ WDSAT 226_ GTLVK 231_ SHLIA 236_ NADVQ 241_ SIAVA 246_ DQEDS 251_ FVVGT 256_ AEGTV 261_ FHFQL 266_ VPVTS 271_ NSSEK 276_ QWVRT 281_ KPFQH 286_ HTHDV 291_ RTVAH 296_ SPTAL 301_ ISGGT 306_ DTHLV 311_ FRPLM 316_ EKVEV 321_ KNYDA 326_ ALRKI 331_ TFPHR 336_ CLISC 341_ SKKRQ 346_ LLLFQ 351_ FAHHL 356_ ELWRL 361_ GSTVA 366_ TGKNG 371_ DTLPL 376_ SKNAD 381_ HLLHL 386_ KTKGP 391_ ENIIC 396_ SCISP 401_ CGSWI 406_ AYSTV 411_ SRFFL 416_ YRLNY 421_ EHDNI 426_ SLKRV 431_ SKMPA 436_ FLRSA 441_ LQILF 446_ SEDST 451_ KLFVA 456_ SNQGA 461_ LHIVQ 466_ LSGGS 471_ FKHLH 476_ AFQPQ 481_ SGTVE 486_ AMCLL 491_ AVSPD 496_ GNWLA 501_ ASGTS 506_ AGVHV 511_ YNVKQ 516_ LKLHC 521_ TVPAY 526_ NFPVT 531_ AMAIA 536_ PNTNN 541_ LVIAH 546_ SDQQV 551_ FEYSI 556_ PDKQY 561_ TDWSR 566_ TVQKQ 571_ GFHHL 576_ WLQRD 581_ TPITH 586_ ISFHP 591_ KRPMH 596_ ILLHD 601_ AYMFC 606_ IIDKS 611_ LPLPN 616_ DKTLL 621_ YNPFP 626_ PTNES 631_ DVIRR 636_ RTAHA 641_ FKISK 646_ IYKPL 651_ LFMDL 656_ LDERT 661_ LVAVE 666_ RPLDD 671_ IIAQL 676_ PPPIK 681_KKKFG
1: Ribosome biogenesis factor. Involved in nucleolar processing of pre-18S ribosomal RNA. Part of the small subunit (SSU) processome, first precursor of the small eukaryotic ribosomal subunit. During the assembly of the SSU processome in the nucleolus, many ribosome biogenesis factors, an RNA chaperone and ribosomal proteins associate with the nascent pre-rRNA and work in concert to generate RNA folding, modifications, rearrangements and cleavage as well as targeted d Involved in SSU pre-rRNA processing at sites A', A0, 1 and 2b. Required for optimal pre-ribosomal RNA transcription by RNA polymerase (PubMed:17699751, PubMed:19732766, PubMed:34516797). May be a transcriptional regulator (PubMed:22916032)
2: (Microbial infection) Acts as a positive regulator of HIVEP1 which specifically binds to the DNA sequence 5'-GGGACTTTCC-3' found in enhancer elements of numerous viral promoters such as those of HIV-1, SV40, or CMV