Histone H2B type 1-A (Histone H2B, testis) (TSH2B.1) (hTSH2B) (Testis-specific histone H2B)
1_MPEVS 6_ SKGAT 11_ ISKKG 16_ FKKAV 21_ VKTQK 26_ KEGKK 31_ RKRTR 36_ KESYS 41_ IYIYK 46_ VLKQV 51_ HPDTG 56_ ISSKA 61_ MSIMN 66_ SFVTD 71_ IFERI 76_ ASEAS 81_ RLAHY 86_ SKRST 91_ ISSRE 96_ IQTAV 101_ RLLLP 106_ GELAK 111_ HAVSE 116_ GTKAV 121_TKYTS
1: Variant histone specifically required to direct the transformation of dissociating nucleosomes to protamine in male germ cells (By similarity). Entirely replaces classical histone H2B prior nucleosome to protamine transition and probably acts as a nucleosome dissociating factor that creates a more dynamic chromatin, facilitating the large-scale exchange of histones (By similarity). Core component of nucleosome (By similarity). Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template (By similarity). Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability (By similarity). DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling (By similarity). Also found in fat cells, its function and the presence of post-translational modifications specific to such cells are still unclear (PubMed:21249133)