Terminal nucleotidyltransferase 5B (EC 2.7.7.19) (Non-canonical poly(A) polymerase FAM46B)
1_MMPSE 6_ SGAER 11_ RDRAA 16_ AQVGT 21_ AAATA 26_ VATAA 31_ PAGGG 36_ PDPEA 41_ LSAFP 46_ GRHLS 51_ GLSWP 56_ QVKRL 61_ DALLS 66_ EPIPI 71_ HGRGN 76_ FPTLS 81_ VQPRQ 86_ IVQVV 91_ RSTLE 96_ EQGLH 101_ VHSVR 106_ LHGSA 111_ ASHVL 116_ HPESG 121_ LGYKD 126_ LDLVF 131_ RVDLR 136_ SEASF 141_ QLTKA 146_ VVLAC 151_ LLDFL 156_ PAGVS 161_ RAKIT 166_ PLTLK 171_ EAYVQ 176_ KLVKV 181_ CTDSD 186_ RWSLI 191_ SLSNK 196_ SGKNV 201_ ELKFV 206_ DSVRR 211_ QFEFS 216_ IDSFQ 221_ IILDS 226_ LLLFG 231_ QCSST 236_ PMSEA 241_ FHPTV 246_ TGESL 251_ YGDFT 256_ EALEH 261_ LRHRV 266_ IATRS 271_ PEEIR 276_ GGGLL 281_ KYCHL 286_ LVRGF 291_ RPRPS 296_ TDVRA 301_ LQRYM 306_ CSRFF 311_ IDFPD 316_ LVEQR 321_ RTLER 326_ YLEAH 331_ FGGAD 336_ AARRY 341_ ACLVT 346_ LHRVV 351_ NESTV 356_ CLMNH 361_ ERRQT 366_ LDLIA 371_ ALALQ 376_ ALAEQ 381_ GPAAT 386_ AALAW 391_ RPPGT 396_ DGVVP 401_ ATVNY 406_ YVTPV 411_ QPLLA 416_HAYPT
1: Catalyzes the transfer of one adenosine molecule from an ATP to an mRNA poly(A) tail bearing a 3'-OH terminal group in an ATP hydrolysis-dependent manner (PubMed:32009146, PubMed:34048638). May be involved in maintaining the translation efficiency of at least some genes through preventing degradation of their mRNAs (PubMed:32009146). Prefers RNA molecules that are adenosine-rich close to 3'-end (PubMed:32009146). In addition, may inhibit cell proliferation and cell cycle progression through ubiquitination of beta-catenin/CTNNB1 (PubMed:30532005)