Transmembrane protein 106A
1_MGKTF 6_ SQLGS 11_ WREDE 16_ NKSIL 21_ SSKPA 26_ IGSKA 31_ VNYSS 36_ TGSSK 41_ SFCSC 46_ VPCEG 51_ TADAS 56_ FVTCP 61_ TCQGS 66_ GKIPQ 71_ ELEKQ 76_ LVALI 81_ PYGDQ 86_ RLKPK 91_ HTKLF 96_ VFLAV 101_ LICLV 106_ TSSFI 111_ VFFLF 116_ PRSVI 121_ VQPAG 126_ LNSST 131_ VAFDE 136_ ADIYL 141_ NITNI 146_ LNISN 151_ GNYYP 156_ IMVTQ 161_ LTLEV 166_ LHLSL 171_ VVGQV 176_ SNNLL 181_ LHIGP 186_ LASEQ 191_ MFYAV 196_ ATKIR 201_ DENTY 206_ KICTW 211_ LEIKV 216_ HHVLL 221_ HIQGT 226_ LTCSY 231_ LSHSE 236_ QLVFQ 241_ SYEYV 246_ DCRGN 251_ ASVPH 256_QLTPH
1: Activates macrophages and polarizes them into M1-like macrophages through the activation of the MAPK and NF-kappaB signaling pathway. Upon activation, up-regulates the expression of CD80, CD86, CD69 and MHC II on macrophages, and induces the release of pro-inflammatory cytokines such as TNF, IL1B, IL6, CCL2 and nitric oxide (By similarity). May play a role in inhibition of proliferation and migration (PubMed:29131025, PubMed:30456879)