Protein FAM162A (E2-induced gene 5 protein) (Growth and transformation-dependent protein) (HGTD-P)
1_MGSLS 6_ GLRLA 11_ AGSCF 16_ RLCER 21_ DVSSS 26_ LRLTR 31_ SSDLK 36_ RINGF 41_ CTKPQ 46_ ESPGA 51_ PSRTY 56_ NRVPL 61_ HKPTD 66_ WQKKI 71_ LIWSG 76_ RFKKE 81_ DEIPE 86_ TVSLE 91_ MLDAA 96_ KNKMR 101_ VKISY 106_ LMIAL 111_ TVVGC 116_ IFMVI 121_ EGKKA 126_ AQRHE 131_ TLTSL 136_ NLEKK 141_ ARLKE 146_EAAMK
1: Proposed to be involved in regulation of apoptosis; the exact mechanism may differ between cell types/tissues (PubMed:15082785). May be involved in hypoxia-induced cell death of transformed cells implicating cytochrome C release and caspase activation (such as CASP9) and inducing mitochondrial permeability transition (PubMed:15082785). May be involved in hypoxia-induced cell death of neuronal cells probably by promoting release of AIFM1 from mitochondria to cytoplasm and its translocation to the nucleus; however, the involvement of caspases has been reported conflictingly (By similarity)