PAT complex subunit CCDC47 (Calumin) (Coiled-coil domain-containing protein 47)
1_MKAFH 6_ TFCVV 11_ LLVFG 16_ SVSEA 21_ KFDDF 26_ EDEED 31_ IVEYD 36_ DNDFA 41_ EFEDV 46_ MEDSV 51_ TESPQ 56_ RVIIT 61_ EDDED 66_ ETTVE 71_ LEGQD 76_ ENQEG 81_ DFEDA 86_ DTQEG 91_ DTESE 96_ PYDDE 101_ EFEGY 106_ EDKPD 111_ TSSSK 116_ NKDPI 121_ TIVDV 126_ PAHLQ 131_ NSWES 136_ YYLEI 141_ LMVTG 146_ LLAYI 151_ MNYII 156_ GKNKN 161_ SRLAQ 166_ AWFNT 171_ HRELL 176_ ESNFT 181_ LVGDD 186_ GTNKE 191_ ATSTG 196_ KLNQE 201_ NEHIY 206_ NLWCS 211_ GRVCC 216_ EGMLI 221_ QLRFL 226_ KRQDL 231_ LNVLA 236_ RMMRP 241_ VSDQV 246_ QIKVT 251_ MNDED 256_ MDTYV 261_ FAVGT 266_ RKALV 271_ RLQKE 276_ MQDLS 281_ EFCSD 286_ KPKSG 291_ AKYGL 296_ PDSLA 301_ ILSEM 306_ GEVTD 311_ GMMDT 316_ KMVHF 321_ LTHYA 326_ DKIES 331_ VHFSD 336_ QFSGP 341_ KIMQE 346_ EGQPL 351_ KLPDT 356_ KRTLL 361_ FTFNV 366_ PGSGN 371_ TYPKD 376_ MEALL 381_ PLMNM 386_ VIYSI 391_ DKAKK 396_ FRLNR 401_ EGKQK 406_ ADKNR 411_ ARVEE 416_ NFLKL 421_ THVQR 426_ QEAAQ 431_ SRREE 436_ KKRAE 441_ KERIM 446_ NEEDP 451_ EKQRR 456_ LEEAA 461_ LRREQ 466_ KKLEK 471_ KQMKM 476_KQIKV
1: Component of the multi-pass translocon (MPT) complex that mediates insertion of multi-pass membrane proteins into the lipid bilayer of membranes (PubMed:32814900, PubMed:32820719, PubMed:36261522). The MPT complex takes over after the SEC61 complex: following membrane insertion of the first few transmembrane segments of proteins by the SEC61 complex, the MPT complex occludes the lateral gate of the SEC61 complex to promote insertion of subsequent transmembrane regions (PubMed:36261522). Within the MPT complex, the PAT subcomplex sequesters any highly polar regions in the transmembrane domains away from the non-polar membrane environment until they can be buried in the interior of the fully assembled protein (By similarity). Within the PAT subcomplex, CCDC47 occludes the lateral gate of the SEC61 complex (By similarity). Involved in the regulation of calcium ion homeostasis in the ER (PubMed:30401460). Required for proper protein degradation via the ERAD (ER-associated degradation) pathway (PubMed:25009997). Has an essential role in the maintenance of ER organization during embryogenesis (By similarity)