E3 ubiquitin-protein ligase RNF166 (EC 2.3.2.27) (RING finger protein 166) (RING-type E3 ubiquitin transferase RNF166)
1_MAMFR 6_ SLVAS 11_ AQQRQ 16_ PPAGP 21_ AGGDS 26_ GLEAQ 31_ YTCPI 36_ CLEVY 41_ HRPVA 46_ IGSCG 51_ HTFCG 56_ ECLQP 61_ CLQVP 66_ SPLCP 71_ LCRLP 76_ FDPKK 81_ VDKAT 86_ HVEKQ 91_ LSSYK 96_ APCRG 101_ CNKKV 106_ TLAKM 111_ RVHIS 116_ SCLKV 121_ QEQMA 126_ NCPKF 131_ VPVVP 136_ TSQPI 141_ PSNIP 146_ NRSTF 151_ ACPYC 156_ GARNL 161_ DQQEL 166_ VKHCV 171_ ESHRS 176_ DPNRV 181_ VCPIC 186_ SAMPW 191_ GDPSY 196_ KSANF 201_ LQHLL 206_ HRHKF 211_ SYDTF 216_ VDYSI 221_ DEEAA 226_ FQAAL 231_ALSLS
1: E3 ubiquitin-protein ligase that promotes the ubiquitination of different substrates (PubMed:27880896). In turn, participates in different biological processes including interferon production or autophagy (PubMed:26456228, PubMed:27880896). Plays a role in the activation of RNA virus-induced interferon-beta production by promoting the ubiquitination of TRAF3 and TRAF6 (PubMed:26456228). Also plays a role in the early recruitment of autophagy adapters to bacteria (PubMed:27880896). Mediates 'Lys-29' and 'Lys-33'-linked ubiquitination of SQSTM1 leading to xenophagic targeting of bacteria and inhibition of their replication (PubMed:27880896)