SPRY domain-containing SOCS box protein 4 (SSB-4)
1_MGQKL 6_ SGSLK 11_ SVEVR 16_ EPALR 21_ PAKRE 26_ LRGAE 31_ PGRPA 36_ RLDQL 41_ LDMPA 46_ AGLAV 51_ QLRHA 56_ WNPED 61_ RSLNV 66_ FVKDD 71_ DRLTF 76_ HRHPV 81_ AQSTD 86_ GIRGK 91_ VGHAR 96_ GLHAW 101_ QINWP 106_ ARQRG 111_ THAVV 116_ GVATA 121_ RAPLH 126_ SVGYT 131_ ALVGS 136_ DAESW 141_ GWDLG 146_ RSRLY 151_ HDGKN 156_ QPGVA 161_ YPAFL 166_ GPDEA 171_ FALPD 176_ SLLVV 181_ LDMDE 186_ GTLSF 191_ IVDGQ 196_ YLGVA 201_ FRGLK 206_ GKKLY 211_ PVVSA 216_ VWGHC 221_ EVTMR 226_ YINGL 231_ DPEPL 236_ PLMDL 241_ CRRSI 246_ RSALG 251_ RQRLQ 256_ DISSL 261_ PLPQS 266_LKNYL
1: Substrate recognition component of a SCF-like ECS (Elongin BC-CUL2/5-SOCS-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins (PubMed:15601820, PubMed:21199876). Negatively regulates nitric oxide (NO) production and limits cellular toxicity in activated macrophages by mediating the ubiquitination and proteasomal degradation of NOS2 (PubMed:21199876). Acts as a bridge which links NOS2 with the ECS E3 ubiquitin ligase complex components ELOC and CUL5 (PubMed:21199876). Diminishes EphB2-dependent cell repulsive responses by mediating the ubiquitination and degradation of EphB2/CTF2 (PubMed:28931592). Regulates cellular clock function by mediating the ubiquitin/proteasome-dependent degradation of the circadian transcriptional repressor NR1D1 (PubMed:26392558)