Tumor protein p53-inducible nuclear protein 1 (Stress-induced protein) (p53-dependent damage-inducible nuclear protein 1) (p53DINP1)
1_MFQRL 6_ NKMFV 11_ GEVSS 16_ SSNQE 21_ PEFNE 26_ KEDDE 31_ WILVD 36_ FIDTC 41_ TGFSA 46_ EEEEE 51_ EEDIS 56_ EESPT 61_ EHPSV 66_ FSCLP 71_ ASLEC 76_ LADTS 81_ DSCFL 86_ QFESC 91_ PMEES 96_ WFITP 101_ PPCFT 106_ AGGLT 111_ TIKVE 116_ TSPME 121_ NLLIE 126_ HPSMS 131_ VYAVH 136_ NSCPG 141_ LSEAT 146_ RGTDE 151_ LHSPS 156_ SPRVE 161_ AQNEM 166_ GQHIH 171_ CYVAA 176_ LAAHT 181_ TFLEQ 186_ PKSFR 191_ PSQWI 196_ KEHSE 201_ RQPLN 206_ RNSLR 211_ RQNLT 216_ RDCHP 221_ RQVKH 226_ NGWVV 231_HQPCP
1: Antiproliferative and proapoptotic protein involved in cell stress response which acts as a dual regulator of transcription and autophagy. Acts as a positive regulator of autophagy. In response to cellular stress or activation of autophagy, relocates to autophagosomes where it interacts with autophagosome-associated proteins GABARAP, GABARAPL1/L2, MAP1LC3A/B/C and regulates autophagy. Acts as an antioxidant and plays a major role in p53/TP53-driven oxidative stress response. Possesses both a p53/TP53-independent intracellular reactive oxygen species (ROS) regulatory function and a p53/TP53-dependent transcription regulatory function. Positively regulates p53/TP53 and p73/TP73 and stimulates their capacity to induce apoptosis and regulate cell cycle. In response to double-strand DNA breaks, promotes p53/TP53 phosphorylation on 'Ser-46' and subsequent apoptosis. Acts as a tumor suppressor by inducing cell death by an autophagy and caspase-dependent mechanism. Can reduce cell migration by regulating the expression of SPARC