Ras-related and estrogen-regulated growth inhibitor (EC 3.6.5.2)
1_MAKSA 6_ EVKLA 11_ IFGRA 16_ GVGKS 21_ ALVVR 26_ FLTKR 31_ FIWEY 36_ DPTLE 41_ STYRH 46_ QATID 51_ DEVVS 56_ MEILD 61_ TAGQE 66_ DTIQR 71_ EGHMR 76_ WGEGF 81_ VLVYD 86_ ITDRG 91_ SFEEV 96_ LPLKN 101_ ILDEI 106_ KKPKN 111_ VTLIL 116_ VGNKA 121_ DLDHS 126_ RQVST 131_ EEGEK 136_ LATEL 141_ ACAFY 146_ ECSAC 151_ TGEGN 156_ ITEIF 161_ YELCR 166_ EVRRR 171_ RMVQG 176_ KTRRR 181_ SSTTH 186_ VKQAI 191_NKMLT
1: Binds GDP/GTP and possesses intrinsic GTPase activity. Has higher affinity for GDP than for GTP. In cell lines overexpression leads to a reduction in the rate of proliferation, colony formation and in tumorigenic potential