Gene name: TRIM52

Uniprot entry:

Q96A61

Protein names:

E3 ubiquitin-protein ligase TRIM52 (EC 2.3.2.27) (RING finger protein 102) (Tripartite motif-containing protein 52)

Protein sequence:

1_MAGYA 6_ TTPSP 11_ MQTLQ 16_ EEAVC 21_ AICLD 26_ YFKDP 31_ VSISC 36_ GHNFC 41_ RGCVT 46_ QLWSK 51_ EDEED 56_ QNEEE 61_ DEWEE 66_ EEDEE 71_ AVGAM 76_ DGWDG 81_ SIREV 86_ LYRGN 91_ ADEEL 96_ FQDQD 101_ DDELW 106_ LGDSG 111_ ITNWD 116_ NVDYM 121_ WDEEE 126_ EEEEE 131_ DQDYY 136_ LGGLR 141_ PDLRI 146_ DVYRE 151_ EEILE 156_ AYDED 161_ EDEEL 166_ YPDIH 171_ PPPSL 176_ PLPGQ 181_ FTCPQ 186_ CRKSF 191_ TRRSF 196_ RPNLQ 201_ LANMV 206_ QIIRQ 211_ MCPTP 216_ YRGNR 221_ SNDQG 226_ MCFKH 231_ QEALK 236_ LFCEV 241_ DKEAI 246_ CVVCR 251_ ESRSH 256_ KQHSV 261_ LPLEE 266_ VVQEY 271_ QEIKL 276_ ETTLV 281_ GILQI 286_ EQESI 291_HSKAY

Protein annotations

Protein functions:

1: E3 ubiquitin-protein ligase (PubMed:27667714). Positively regulates the NF-kappa-B signaling pathway (PubMed:27667714, PubMed:28073078)

2: (Microbial infection) Exhibits antiviral activity against Japanese encephalitis virus (JEV). Ubiquitinates the viral non-structural protein 2 (NS2A) and targets it for proteasome-mediated degradation