Antizyme inhibitor 2 (AzI2) (Arginine decarboxylase) (ADC) (ARGDC) (Ornithine decarboxylase-like protein) (ODC-like protein) (ornithine decarboxylase paralog) (ODC-p)
1_MAGYL 6_ SESDF 11_ VMVEE 16_ GFSTR 21_ DLLKE 26_ LTLGA 31_ SQATT 36_ DEVAA 41_ FFVAD 46_ LGAIV 51_ RKHFC 56_ FLKCL 61_ PRVRP 66_ FYAVK 71_ CNSSP 76_ GVLKV 81_ LAQLG 86_ LGFSC 91_ ANKAE 96_ MELVQ 101_ HIGIP 106_ ASKII 111_ CANPC 116_ KQIAQ 121_ IKYAA 126_ KHGIQ 131_ LLSFD 136_ NEMEL 141_ AKVVK 146_ SHPSA 151_ KMVLC 156_ IATDD 161_ SHSLS 166_ CLSLK 171_ FGVSL 176_ KSCRH 181_ LLENA 186_ KKHHV 191_ EVVGV 196_ SFHIG 201_ SGCPD 206_ PQAYA 211_ QSIAD 216_ ARLVF 221_ EMGTE 226_ LGHKM 231_ HVLDL 236_ GGGFP 241_ GTEGA 246_ KVRFE 251_ EIASV 256_ INSAL 261_ DLYFP 266_ EGCGV 271_ DIFAE 276_ LGRYY 281_ VTSAF 286_ TVAVS 291_ IIAKK 296_ EVLLD 301_ QPGRE 306_ EENGS 311_ TSKTI 316_ VYHLD 321_ EGVYG 326_ IFNSV 331_ LFDNI 336_ CPTPI 341_ LQKKP 346_ STEQP 351_ LYSSS 356_ LWGPA 361_ VDGCD 366_ CVAEG 371_ LWLPQ 376_ LHVGD 381_ WLVFD 386_ NMGAY 391_ TVGMG 396_ SPFWG 401_ TQACH 406_ ITYAM 411_ SRVAW 416_ EALRR 421_ QLMAA 426_ EQEDD 431_ VEGVC 436_ KPLSC 441_ GWEIT 446_ DTLCV 451_GPVFT
1: Antizyme inhibitor (AZI) protein that positively regulates ornithine decarboxylase (ODC) activity and polyamine uptake. AZI is an enzymatically inactive ODC homolog that counteracts the negative effect of ODC antizymes (AZs) OAZ1, OAZ2 and OAZ3 on ODC activity by competing with ODC for antizyme-binding (PubMed:17900240). Inhibits antizyme-dependent ODC degradation and releases ODC monomers from their inactive complex with antizymes, leading to formation of the catalytically active ODC homodimer and restoring polyamine production (PubMed:17900240). Participates in the morphological integrity of the trans-Golgi network (TGN) and functions as a regulator of intracellular secretory vesicle trafficking (PubMed:20188728)