Tuberoinfundibular peptide of 39 residues (TIP39) (Parathyroid hormone 2)
1_METRQ 6_ VSRSP 11_ RVRLL 16_ LLLLL 21_ LLVVP 26_ WGVRT 31_ ASGVA 36_ LPPVG 41_ VLSLR 46_ PPGRA 51_ WADPA 56_ TPRPR 61_ RSLAL 66_ ADDAA 71_ FRERA 76_ RLLAA 81_ LERRH 86_ WLNSY 91_MHKLL
1: Plays a role as a potent and selective agonist of PTH2R resulting in adenyl cyclase activation and intracellular calcium levels elevation. Induces protein kinase C beta activation, recruitment of beta-arrestin and PTH2R internalization. May inhibit cell proliferation via its action on PTH2R activation. Neuropeptide which may also have a role in spermatogenesis. May activate nociceptors and nociceptive circuits