Protein RFT1 homolog
1_MGSQE 6_ VLGHA 11_ ARLAS 16_ SGLLL 21_ QVLFR 26_ LITFV 31_ LNAFI 36_ LRFLS 41_ KEIVG 46_ VVNVR 51_ LTLLY 56_ STTLF 61_ LAREA 66_ FRRAC 71_ LSGGT 76_ QRDWS 81_ QTLNL 86_ LWLTV 91_ PLGVF 96_ WSLFL 101_ GWIWL 106_ QLLEV 111_ PDPNV 116_ VPHYA 121_ TGVVL 126_ FGLSA 131_ VVELL 136_ GEPFW 141_ VLAQA 146_ HMFVK 151_ LKVIA 156_ ESLSV 161_ ILKSV 166_ LTAFL 171_ VLWLP 176_ HWGLY 181_ IFSLA 186_ QLFYT 191_ TVLVL 196_ CYVIY 201_ FTKLL 206_ GSPES 211_ TKLQT 216_ LPVSR 221_ ITDLL 226_ PNITR 231_ NGAFI 236_ NWKEA 241_ KLTWS 246_ FFKQS 251_ FLKQI 256_ LTEGE 261_ RYVMT 266_ FLNVL 271_ NFGDQ 276_ GVYDI 281_ VNNLG 286_ SLVAR 291_ LIFQP 296_ IEESF 301_ YIFFA 306_ KVLER 311_ GKDAT 316_ LQKQE 321_ DVAVA 326_ AAVLE 331_ SLLKL 336_ ALLAG 341_ LTITV 346_ FGFAY 351_ SQLAL 356_ DIYGG 361_ TMLSS 366_ GSGPV 371_ LLRSY 376_ CLYVL 381_ LLAIN 386_ GVTEC 391_ FTFAA 396_ MSKEE 401_ VDRYN 406_ FVMLA 411_ LSSSF 416_ LVLSY 421_ LLTRW 426_ CGSVG 431_ FILAN 436_ CFNMG 441_ IRITQ 446_ SLCFI 451_ HRYYR 456_ RSPHR 461_ PLAGL 466_ HLSPV 471_ LLGTF 476_ ALSGG 481_ VTAVS 486_ EVFLC 491_ CEQGW 496_ PARLA 501_ HIAVG 506_ AFCLG 511_ ATLGT 516_ AFLTE 521_ TKLIH 526_ FLRTQ 531_ LGVPR 536_RTDKM
1: Intramembrane glycolipid transporter that operates in the biosynthetic pathway of dolichol-linked oligosaccharides, the glycan precursors employed in protein asparagine (N)-glycosylation. The sequential addition of sugars to dolichol pyrophosphate produces dolichol-linked oligosaccharides containing fourteen sugars, including two GlcNAcs, nine mannoses and three glucoses. Once assembled, the oligosaccharide is transferred from the lipid to nascent proteins by oligosaccharyltransferases. The assembly of dolichol-linked oligosaccharides begins on the cytosolic side of the endoplasmic reticulum membrane and finishes in its lumen. RFT1 could mediate the translocation of the cytosolically oriented intermediate DolPP-GlcNAc2Man5, produced by ALG11, into the ER lumen where dolichol-linked oligosaccharides assembly continues (PubMed:18313027, PubMed:19701946). However, the intramembrane lipid transporter activity could not be confirmed in vitro (By similarity)