Fermitin family homolog 2 (Kindlin-2) (Mitogen-inducible gene 2 protein) (MIG-2) (Pleckstrin homology domain-containing family C member 1) (PH domain-containing family C member 1)
1_MALDG 6_ IRMPD 11_ GCYAD 16_ GTWEL 21_ SVHVT 26_ DLNRD 31_ VTLRV 36_ TGEVH 41_ IGGVM 46_ LKLVE 51_ KLDVK 56_ KDWSD 61_ HALWW 66_ EKKRT 71_ WLLKT 76_ HWTLD 81_ KYGIQ 86_ ADAKL 91_ QFTPQ 96_ HKLLR 101_ LQLPN 106_ MKYVK 111_ VKVNF 116_ SDRVF 121_ KAVSD 126_ ICKTF 131_ NIRHP 136_ EELSL 141_ LKKPR 146_ DPTKK 151_ KKKKL 156_ DDQSE 161_ DEALE 166_ LEGPL 171_ ITPGS 176_ GSIYS 181_ SPGLY 186_ SKTMT 191_ PTYDA 196_ HDGSP 201_ LSPTS 206_ AWFGD 211_ SALSE 216_ GNPGI 221_ LAVSQ 226_ PITSP 231_ EILAK 236_ MFKPQ 241_ ALLDK 246_ AKINQ 251_ GWLDS 256_ SRSLM 261_ EQDVK 266_ ENEAL 271_ LLRFK 276_ YYSFF 281_ DLNPK 286_ YDAIR 291_ INQLY 296_ EQAKW 301_ AILLE 306_ EIECT 311_ EEEMM 316_ MFAAL 321_ QYHIN 326_ KLSIM 331_ TSENH 336_ LNNSD 341_ KEVDE 346_ VDAAL 351_ SDLEI 356_ TLEGG 361_ KTSTI 366_ LGDIT 371_ SIPEL 376_ ADYIK 381_ VFKPK 386_ KLTLK 391_ GYKQY 396_ WCTFK 401_ DTSIS 406_ CYKSK 411_ EESSG 416_ TPAHQ 421_ MNLRG 426_ CEVTP 431_ DVNIS 436_ GQKFN 441_ IKLLI 446_ PVAEG 451_ MNEIW 456_ LRCDN 461_ EKQYA 466_ HWMAA 471_ CRLAS 476_ KGKTM 481_ ADSSY 486_ NLEVQ 491_ NILSF 496_ LKMQH 501_ LNPDP 506_ QLIPE 511_ QITTD 516_ ITPEC 521_ LVSPR 526_ YLKKY 531_ KNKQI 536_ TARIL 541_ EAHQN 546_ VAQMS 551_ LIEAK 556_ MRFIQ 561_ AWQSL 566_ PEFGI 571_ THFIA 576_ RFQGG 581_ KKEEL 586_ IGIAY 591_ NRLIR 596_ MDAST 601_ GDAIK 606_ TWRFS 611_ NMKQW 616_ NVNWE 621_ IKMVT 626_ VEFAD 631_ EVRLS 636_ FICTE 641_ VDCKV 646_ VHEFI 651_ GGYIF 656_ LSTRA 661_ KDQNE 666_ SLDEE 671_MFYKL
1: Scaffolding protein that enhances integrin activation mediated by TLN1 and/or TLN2, but activates integrins only weakly by itself. Binds to membranes enriched in phosphoinositides. Enhances integrin-mediated cell adhesion onto the extracellular matrix and cell spreading; this requires both its ability to interact with integrins and with phospholipid membranes. Required for the assembly of focal adhesions. Participates in the connection between extracellular matrix adhesion sites and the actin cytoskeleton and also in the orchestration of actin assembly and cell shape modulation. Recruits FBLIM1 to focal adhesions. Plays a role in the TGFB1 and integrin signaling pathways. Stabilizes active CTNNB1 and plays a role in the regulation of transcription mediated by CTNNB1 and TCF7L2/TCF4 and in Wnt signaling