Patatin-like phospholipase domain-containing protein 2 (EC 3.1.1.3) (Adipose triglyceride lipase) (Calcium-independent phospholipase A2-zeta) (iPLA2-zeta) (EC 3.1.1.4) (Desnutrin) (Pigment epithelium-derived factor receptor) (PEDF-R) (TTS2.2) (Transport-secretion protein 2) (TTS2)
1_MFPRE 6_ KTWNI 11_ SFAGC 16_ GFLGV 21_ YYVGV 26_ ASCLR 31_ EHAPF 36_ LVANA 41_ THIYG 46_ ASAGA 51_ LTATA 56_ LVTGV 61_ CLGEA 66_ GAKFI 71_ EVSKE 76_ ARKRF 81_ LGPLH 86_ PSFNL 91_ VKIIR 96_ SFLLK 101_ VLPAD 106_ SHEHA 111_ SGRLG 116_ ISLTR 121_ VSDGE 126_ NVIIS 131_ HFNSK 136_ DELIQ 141_ ANVCS 146_ GFIPV 151_ YCGLI 156_ PPSLQ 161_ GVRYV 166_ DGGIS 171_ DNLPL 176_ YELKN 181_ TITVS 186_ PFSGE 191_ SDICP 196_ QDSST 201_ NIHEL 206_ RVTNT 211_ SIQFN 216_ LRNLY 221_ RLSKA 226_ LFPPE 231_ PLVLR 236_ EMCKQ 241_ GYRDG 246_ LRFLQ 251_ RNGLL 256_ NRPNP 261_ LLALP 266_ PARPH 271_ GPEDK 276_ DQAVE 281_ SAQAE 286_ DYSQL 291_ PGEDH 296_ ILEHL 301_ PARLN 306_ EALLE 311_ ACVEP 316_ TDLLT 321_ TLSNM 326_ LPVRL 331_ ATAMM 336_ VPYTL 341_ PLESA 346_ LSFTI 351_ RLLEW 356_ LPDVP 361_ EDIRW 366_ MKEQT 371_ GSICQ 376_ YLVMR 381_ AKRKL 386_ GRHLP 391_ SRLPE 396_ QVELR 401_ RVQSL 406_ PSVPL 411_ SCAAY 416_ REALP 421_ GWMRN 426_ NLSLG 431_ DALAK 436_ WEECQ 441_ RQLLL 446_ GLFCT 451_ NVAFP 456_ PEALR 461_ MRAPA 466_ DPAPA 471_ PADPA 476_ SPQHQ 481_ LAGPA 486_ PLLST 491_ PAPEA 496_RPVIG
1: Catalyzes the initial step in triglyceride hydrolysis in adipocyte and non-adipocyte lipid droplets (PubMed:15364929, PubMed:15550674, PubMed:16150821, PubMed:16239926, PubMed:17603008, PubMed:34903883). Exhibits a strong preference for the hydrolysis of long-chain fatty acid esters at the sn-2 position of the glycerol backbone and acts coordinately with LIPE/HLS and DGAT2 within the lipolytic cascade (By similarity). Also possesses acylglycerol transacylase and phospholipase A2 activities (PubMed:15364929, PubMed:17032652, PubMed:17603008). Transfers fatty acid from triglyceride to retinol, hydrolyzes retinylesters, and generates 1,3-diacylglycerol from triglycerides (PubMed:17603008). Regulates adiposome size and may be involved in the degradation of adiposomes (PubMed:16239926). Catalyzes the formation of an ester bond between hydroxy fatty acids and fatty acids derived from triglycerides or diglycerides to generate fatty acid esters of hydroxy fatty acids (FAHFAs) in adipocytes (PubMed:35676490). Acts antagonistically with LDAH in regulation of cellular lipid stores (PubMed:28578400). Inhibits LDAH-stimulated lipid droplet fusion (PubMed:28578400). May play an important role in energy homeostasis (By similarity). May play a role in the response of the organism to starvation, enhancing hydrolysis of triglycerides and providing free fatty acids to other tissues to be oxidized in situations of energy depletion (By similarity)