SOSS complex subunit B2 (Nucleic acid-binding protein 1) (Oligonucleotide/oligosaccharide-binding fold-containing protein 2A) (Sensor of single-strand DNA complex subunit B2) (Sensor of ssDNA subunit B2) (SOSS-B2) (Single-stranded DNA-binding protein 2) (hSSB2)
1_MNRVN 6_ DPLIF 11_ IRDIK 16_ PGLKN 21_ LNVVF 26_ IVLEI 31_ GRVTK 36_ TKDGH 41_ EVRSC 46_ KVADK 51_ TGSIT 56_ ISVWD 61_ EIGGL 66_ IQPGD 71_ IIRLT 76_ RGYAS 81_ MWKGC 86_ LTLYT 91_ GRGGE 96_ LQKIG 101_ EFCMV 106_ YSEVP 111_ NFSEP 116_ NPDYR 121_ GQQNK 126_ GAQSE 131_ QKNNS 136_ MNSNM 141_ GTGTF 146_ GPVGN 151_ GVHTG 156_ PESRE 161_ HQFSH 166_ AGRSN 171_ GRGLI 176_ NPQLQ 181_ GTASN 186_ QTVMT 191_ TISNG 196_RDPRR
1: Component of the SOSS complex, a multiprotein complex that functions downstream of the MRN complex to promote DNA repair and G2/M checkpoint. In the SOSS complex, acts as a sensor of single-stranded DNA that binds to single-stranded DNA, in particular to polypyrimidines. The SOSS complex associates with DNA lesions and influences diverse endpoints in the cellular DNA damage response including cell-cycle checkpoint activation, recombinational repair and maintenance of genomic stability. Required for efficient homologous recombination-dependent repair of double-strand breaks (DSBs) and ATM-dependent signaling pathways