Ras-related protein Rab-7b
1_MNPRK 6_ KVDLK 11_ LIIVG 16_ AIGVG 21_ KTSLL 26_ HQYVH 31_ KTFYE 36_ EYQTT 41_ LGASI 46_ LSKII 51_ ILGDT 56_ TLKLQ 61_ IWDTG 66_ GQERF 71_ RSMVS 76_ TFYKG 81_ SDGCI 86_ LAFDV 91_ TDLES 96_ FEALD 101_ IWRGD 106_ VLAKI 111_ VPMEQ 116_ SYPMV 121_ LLGNK 126_ IDLAD 131_ RKVPQ 136_ EVAQG 141_ WCREK 146_ DIPYF 151_ EVSAK 156_ NDINV 161_ VQAFE 166_ MLASR 171_ ALSRY 176_ QSILE 181_ NHLTE 186_ SIKLS 191_PDQSR
1: Controls vesicular trafficking from endosomes to the trans-Golgi network (TGN). Acts as a negative regulator of TLR9 signaling and can suppress TLR9-triggered TNFA, IL6, and IFNB production in macrophages by promoting TLR9 lysosomal degradation. Also negatively regulates TLR4 signaling in macrophages by promoting lysosomal degradation of TLR4. Promotes megakaryocytic differentiation by increasing NF-kappa-B-dependent IL6 production and subsequently enhancing the association of STAT3 with GATA1. Not involved in the regulation of the EGF- and EGFR degradation pathway