DNA dC->dU-editing enzyme APOBEC-3D (A3D) (A3DE) (EC 3.5.4.38)
1_MNPQI 6_ RNPME 11_ RMYRD 16_ TFYDN 21_ FENEP 26_ ILYGR 31_ SYTWL 36_ CYEVK 41_ IKRGR 46_ SNLLW 51_ DTGVF 56_ RGPVL 61_ PKRQS 66_ NHRQE 71_ VYFRF 76_ ENHAE 81_ MCFLS 86_ WFCGN 91_ RLPAN 96_ RRFQI 101_ TWFVS 106_ WNPCL 111_ PCVVK 116_ VTKFL 121_ AEHPN 126_ VTLTI 131_ SAARL 136_ YYYRD 141_ RDWRW 146_ VLLRL 151_ HKAGA 156_ RVKIM 161_ DYEDF 166_ AYCWE 171_ NFVCN 176_ EGQPF 181_ MPWYK 186_ FDDNY 191_ ASLHR 196_ TLKEI 201_ LRNPM 206_ EAMYP 211_ HIFYF 216_ HFKNL 221_ LKACG 226_ RNESW 231_ LCFTM 236_ EVTKH 241_ HSAVF 246_ RKRGV 251_ FRNQV 256_ DPETH 261_ CHAER 266_ CFLSW 271_ FCDDI 276_ LSPNT 281_ NYEVT 286_ WYTSW 291_ SPCPE 296_ CAGEV 301_ AEFLA 306_ RHSNV 311_ NLTIF 316_ TARLC 321_ YFWDT 326_ DYQEG 331_ LCSLS 336_ QEGAS 341_ VKIMG 346_ YKDFV 351_ SCWKN 356_ FVYSD 361_ DEPFK 366_ PWKGL 371_ QTNFR 376_ LLKRR 381_LREIL
1: DNA deaminase (cytidine deaminase) which acts as an inhibitor of retrovirus replication and retrotransposon mobility via deaminase-dependent and -independent mechanisms (PubMed:16920826, PubMed:20062055, PubMed:21835787). Exhibits antiviral activity against HIV-1. After the penetration of retroviral nucleocapsids into target cells of infection and the initiation of reverse transcription, it can induce the conversion of cytosine to uracil in the minus-sense single-strand viral DNA, leading to G-to-A hypermutations in the subsequent plus-strand viral DNA (PubMed:16920826). The resultant detrimental levels of mutations in the proviral genome, along with a deamination-independent mechanism that works prior to the proviral integration, together exert efficient antiretroviral effects in infected target cells. Selectively targets single-stranded DNA and does not deaminate double-stranded DNA or single- or double-stranded RNA. Also inhibits the mobility of LTR and non-LTR retrotransposons (PubMed:27428332)
2: (Microbial infection) Enhances hepatitis B virus/HBV replication by excluding restriction factors APOBEC3F and APOBEC3G from HBV capsids