Adrenocortical dysplasia protein homolog (POT1 and TIN2-interacting protein)
1_MAGSG 6_ RLVLR 11_ PWIRE 16_ LILGS 21_ ETPSS 26_ PRAGQ 31_ LLEVL 36_ QDAEA 41_ AVAGP 46_ SHAPD 51_ TSDVG 56_ ATLLV 61_ SDGTH 66_ SVRCL 71_ VTREA 76_ LDTSD 81_ WEEKE 86_ FGFRG 91_ TEGRL 96_ LLLQD 101_ CGVHV 106_ QVAEG 111_ GAPAE 116_ FYLQV 121_ DRFSL 126_ LPTEQ 131_ PRLRV 136_ PGCNQ 141_ DLDVQ 146_ KKLYD 151_ CLEEH 156_ LSEST 161_ SSNAG 166_ LSLSQ 171_ LLDEM 176_ REDQE 181_ HQGAL 186_ VCLAE 191_ SCLTL 196_ EGPCT 201_ APPVT 206_ HWAAS 211_ RCKAT 216_ GEAVY 221_ TVPSS 226_ MLCIS 231_ ENDQL 236_ ILSSL 241_ GPCQR 246_ TQGPE 251_ LPPPD 256_ PALQD 261_ LSLTL 266_ IASPP 271_ SSPSS 276_ SGTPA 281_ LPGHM 286_ SSEES 291_ GTSIS 296_ LLPAL 301_ SLAAP 306_ DPGQR 311_ SSSQP 316_ SPAIC 321_ SAPAT 326_ LTPRS 331_ PHASR 336_ TPSSP 341_ LQSCT 346_ PSLSP 351_ RSHVP 356_ SPHQA 361_ LVTRP 366_ QKPSL 371_ EFKEF 376_ VGLPC 381_ KNRPP 386_ FPRTG 391_ ATRGA 396_ QEPCS 401_ VWEPP 406_ KRHRD 411_ GSAFQ 416_ YEYEP 421_ PCTSL 426_ CARVQ 431_ AVRLP 436_ PQLMA 441_ WALHF 446_ LMDAQ 451_PGSEP
1: Component of the shelterin complex (telosome) that is involved in the regulation of telomere length and protection. Shelterin associates with arrays of double-stranded TTAGGG repeats added by telomerase and protects chromosome ends. Without its protective activity, telomeres are no longer hidden from the DNA damage surveillance and chromosome ends are inappropriately processed by DNA repair pathways. Promotes binding of POT1 to single-stranded telomeric DNA. Modulates the inhibitory effects of POT1 on telomere elongation. The ACD-POT1 heterodimer enhances telomere elongation by recruiting telomerase to telomeres and increasing its processivity. May play a role in organogenesis