Zinc finger-containing ubiquitin peptidase 1 (EC 3.4.19.12) (Lys-63-specific deubiquitinase ZUFSP) (DUB) (Zinc finger with UFM1-specific peptidase domain protein)
1_MLSCN 6_ ICGET 11_ VTSEP 16_ DMKAH 21_ LIVHM 26_ ESEII 31_ CPFCK 36_ LSGVN 41_ YDEMC 46_ FHIET 51_ AHFEQ 56_ NTLER 61_ NFERI 66_ NTVQY 71_ GTSDN 76_ KKDNT 81_ LQCGM 86_ EVNSS 91_ ILSGC 96_ ASNHP 101_ KNSAQ 106_ NLTKD 111_ STLKH 116_ EGFYS 121_ ENLTE 126_ SRKFL 131_ KSREK 136_ QSSLT 141_ EIKGS 146_ VYETT 151_ YSPPE 156_ CPFCG 161_ KIEEH 166_ SEDME 171_ THVKT 176_ KHANL 181_ LDIPL 186_ EDCDQ 191_ PLYDC 196_ PMCGL 201_ ICTNY 206_ HILQE 211_ HVDLH 216_ LEENS 221_ FQQGM 226_ DRVQC 231_ SGDLQ 236_ LAHQL 241_ QQEED 246_ RKRRS 251_ EESRQ 256_ EIEEF 261_ QKLQR 266_ QYGLD 271_ NSGGY 276_ KQQQL 281_ RNMEI 286_ EVNRG 291_ RMPPS 296_ EFHRR 301_ KADMM 306_ ESLAL 311_ GFDDG 316_ KTKTS 321_ GIIEA 326_ LHRYY 331_ QNAAT 336_ DVRRV 341_ WLSSV 346_ VDHFH 351_ SSLGD 356_ KGWGC 361_ GYRNF 366_ QMLLS 371_ SLLQN 376_ DAYND 381_ CLKGM 386_ LIPCI 391_ PKIQS 396_ MIEDA 401_ WKEGF 406_ DPQGA 411_ SQLNN 416_ RLQGT 421_ KAWIG 426_ ACEVY 431_ ILLTS 436_ LRVKC 441_ HIVDF 446_ HKSTG 451_ PLGTH 456_ PRLFE 461_ WILNY 466_ YSSEG 471_ EGSPK 476_ VVCTS 481_ KPPIY 486_ LQHQG 491_ HSRTV 496_ IGIEE 501_ KKNRT 506_ LCLLI 511_ LDPGC 516_ PSREM 521_ QKLLK 526_ QDIEA 531_ SSLKQ 536_ LRKSM 541_ GNLKH 546_ KQYQI 551_ LAVEG 556_ ALSLE 561_ EKLAR 566_ RQASQ 571_VFTAE
1: Deubiquitinase with endodeubiquitinase activity that specifically interacts with and cleaves 'Lys-63'-linked long polyubiquitin chains. Shows only weak activity against 'Lys-11' and 'Lys-48'-linked chains (PubMed:29476094, PubMed:29563501, PubMed:29576528). Plays an important role in genome stability pathways, functioning to prevent spontaneous DNA damage and also promote cellular survival in response to exogenous DNA damage (PubMed:29576527, PubMed:29576528). Modulates the ubiquitination status of replication protein A (RPA) complex proteins in response to replication stress (PubMed:29563501)