Cell death activator CIDE-3 (Cell death-inducing DFFA-like effector protein C) (Fat-specific protein FSP27 homolog)
1_MEYAM 6_ KSLSL 11_ LYPKS 16_ LSRHV 21_ SVRTS 26_ VVTQQ 31_ LLSEP 36_ SPKAP 41_ RARPC 46_ RVSTA 51_ DRSVR 56_ KGIMA 61_ YSLED 66_ LLLKV 71_ RDTLM 76_ LADKP 81_ FFLVL 86_ EEDGT 91_ TVETE 96_ EYFQA 101_ LAGDT 106_ VFMVL 111_ QKGQK 116_ WQPPS 121_ EQGTR 126_ HPLSL 131_ SHKPA 136_ KKIDV 141_ ARVTF 146_ DLYKL 151_ NPQDF 156_ IGCLN 161_ VKATF 166_ YDTYS 171_ LSYDL 176_ HCCGA 181_ KRIMK 186_ EAFRW 191_ ALFSM 196_ QATGH 201_ VLLGT 206_ SCYLQ 211_ QLLDA 216_ TEEGQ 221_ PPKGK 226_ ASSLI 231_PTCLK
1: Lipid transferase specifically expressed in white adipose tissue, which promotes unilocular lipid droplet formation by mediating lipid droplet fusion (PubMed:18334488, PubMed:19843876, PubMed:20049731, PubMed:23399566, PubMed:30361435). Lipid droplet fusion promotes their enlargement, restricting lipolysis and favoring lipid storage (PubMed:18334488, PubMed:19843876, PubMed:20049731, PubMed:23399566). Localizes on the lipid droplet surface, at focal contact sites between lipid droplets, and mediates atypical lipid droplet fusion by undergoing liquid-liquid phase separation (LLPS) and promoting directional net neutral lipid transfer from the smaller to larger lipid droplets (PubMed:18334488, PubMed:19843876, PubMed:20049731, PubMed:23399566). The transfer direction may be driven by the internal pressure difference between the contacting lipid droplet pair (PubMed:18334488, PubMed:19843876, PubMed:20049731, PubMed:23399566). Its role in neutral lipid transfer and lipid droplet enlargement is activated by the interaction with PLIN1 (PubMed:23399566). May also act as a CEBPB coactivator in the white adipose tissue to control the expression of a subset of CEBPB downstream target genes, including SOCS1, SOCS3, TGFB1, TGFBR1, ID2 and XDH (By similarity). When overexpressed in preadipocytes, induces apoptosis or increases cell susceptibility to apoptosis induced by serum deprivation or TGFB treatment (PubMed:12429024)