Transcription factor E2F7 (E2F-7)
1_MEVNC 6_ LTLKD 11_ LISPR 16_ QPRLD 21_ FAVED 26_ GENAQ 31_ KENIF 36_ VDRSR 41_ MAPKT 46_ PIKNE 51_ PIDLS 56_ KQKKF 61_ TPERN 66_ PITPV 71_ KFVDR 76_ QQAEP 81_ WTPTA 86_ NLKML 91_ ISAAS 96_ PDIRD 101_ REKKK 106_ GLFRP 111_ IENKD 116_ DAFTD 121_ SLQLD 126_ VVGDS 131_ AVDEF 136_ EKQRP 141_ SRKQK 146_ SLGLL 151_ CQKFL 156_ ARYPS 161_ YPLST 166_ EKTTI 171_ SLDEV 176_ AVSLG 181_ VERRR 186_ IYDIV 191_ NVLES 196_ LHLVS 201_ RVAKN 206_ QYGWH 211_ GRHSL 216_ PKTLR 221_ NLQRL 226_ GEEQK 231_ YEEQM 236_ AYLQQ 241_ KELDL 246_ IDYKF 251_ GERKK 256_ DGDPD 261_ SQEQQ 266_ LLDFS 271_ EPDCP 276_ SSSAN 281_ SRKDK 286_ SLRIM 291_ SQKFV 296_ MLFLV 301_ SKTKI 306_ VTLDV 311_ AAKIL 316_ IEESQ 321_ DAPDH 326_ SKFKT 331_ KVRRL 336_ YDIAN 341_ VLTSL 346_ ALIKK 351_ VHVTE 356_ ERGRK 361_ PAFKW 366_ IGPVD 371_ FSSSD 376_ EELVD 381_ VSASV 386_ LPELK 391_ RETYG 396_ QIQVC 401_ AKQKL 406_ ARHGS 411_ FNTVQ 416_ ASERI 421_ QRKVN 426_ SEPSS 431_ PYREE 436_ QGSGG 441_ YSLEI 446_ GSLAA 451_ VYRQK 456_ IEDNS 461_ QGKAF 466_ ASKRV 471_ VPPSS 476_ SLDPV 481_ APFPV 486_ LSVDP 491_ EYCVN 496_ PLAHP 501_ VFSVA 506_ QTDLQ 511_ AFSMQ 516_ NGLNG 521_ QVDVS 526_ LASAA 531_ SAVES 536_ LKPAL 541_ LAGQP 546_ LVYVP 551_ SASLF 556_ MLYGS 561_ LQEGP 566_ ASGSG 571_ SERDD 576_ RSSEA 581_ PATVE 586_ LSSAP 591_ SAQKR 596_ LCEER 601_ KPQEE 606_ DEPAT 611_ KRQSR 616_ EYEDG 621_ PLSLV 626_ MPKKP 631_ SDSTD 636_ LASPK 641_ TMGNR 646_ ASIPL 651_ KDIHV 656_ NGQLP 661_ AAEEI 666_ SGKAT 671_ ANSLV 676_ SSEWG 681_ NPSRN 686_ TDVEK 691_ PSKEN 696_ ESTKE 701_ PSLLQ 706_ YLCVQ 711_ SPAGL 716_ NGFNV 721_ LLSGS 726_ QTPPT 731_ VGPSS 736_ GQLPS 741_ FSVPC 746_ MVLPS 751_ PPLGP 756_ FPVLY 761_ SPAMP 766_ GPVSS 771_ TLGAL 776_ PNTGP 781_ VNFSL 786_ PGLGS 791_ IAQLL 796_ VGPTA 801_ VVNPK 806_ SSTLP 811_ SADPQ 816_ LQSQP 821_ SLNLS 826_ PVMSR 831_ SHSVV 836_ QQPES 841_ PVYVG 846_ HPVSV 851_ VKLHQ 856_ SPVPV 861_ TPKSI 866_ QRTHR 871_ ETFFK 876_ TPGSL 881_ GDPVL 886_ KRRER 891_ NQSRN 896_ TSSAQ 901_ RRLEI 906_PSGGA
1: Atypical E2F transcription factor that participates in various processes such as angiogenesis, polyploidization of specialized cells and DNA damage response. Mainly acts as a transcription repressor that binds DNA independently of DP proteins and specifically recognizes the E2 recognition site 5'-TTTC[CG]CGC-3'. Directly represses transcription of classical E2F transcription factors such as E2F1. Acts as a regulator of S-phase by recognizing and binding the E2-related site 5'-TTCCCGCC-3' and mediating repression of G1/S-regulated genes. Plays a key role in polyploidization of cells in placenta and liver by regulating the endocycle, probably by repressing genes promoting cytokinesis and antagonizing action of classical E2F proteins (E2F1, E2F2 and/or E2F3). Required for placental development by promoting polyploidization of trophoblast giant cells. Also involved in DNA damage response: up-regulated by p53/TP53 following genotoxic stress and acts as a downstream effector of p53/TP53-dependent repression by mediating repression of indirect p53/TP53 target genes involved in DNA replication. Acts as a promoter of sprouting angiogenesis, possibly by acting as a transcription activator: associates with HIF1A, recognizes and binds the VEGFA promoter, which is different from canonical E2 recognition site, and activates expression of the VEGFA gene. Acts as a negative regulator of keratinocyte differentiation