Vacuolar protein sorting-associated protein 33A (hVPS33A)
1_MAAHL 6_ SYGRV 11_ NLNVL 16_ REAVR 21_ RELRE 26_ FLDKC 31_ AGSKA 36_ IVWDE 41_ YLTGP 46_ FGLIA 51_ QYSLL 56_ KEHEV 61_ EKMFT 66_ LKGNR 71_ LPAAD 76_ VKNII 81_ FFVRP 86_ RLELM 91_ DIIAE 96_ NVLSE 101_ DRRGP 106_ TRDFH 111_ ILFVP 116_ RRSLL 121_ CEQRL 126_ KDLGV 131_ LGSFI 136_ HREEY 141_ SLDLI 146_ PFDGD 151_ LLSME 156_ SEGAF 161_ KECYL 166_ EGDQT 171_ SLYHA 176_ AKGLM 181_ TLQAL 186_ YGTIP 191_ QIFGK 196_ GECAR 201_ QVANM 206_ MIRMK 211_ REFTG 216_ SQNSI 221_ FPVFD 226_ NLLLL 231_ DRNVD 236_ LLTPL 241_ ATQLT 246_ YEGLI 251_ DEIYG 256_ IQNSY 261_ VKLPP 266_ EKFAP 271_ KKQGD 276_ GGKDL 281_ PTEAK 286_ KLQLN 291_ SAEEL 296_ YAEIR 301_ DKNFN 306_ AVGSV 311_ LSKKA 316_ KIISA 321_ AFEER 326_ HNAKT 331_ VGEIK 336_ QFVSQ 341_ LPHMQ 346_ AARGS 351_ LANHT 356_ SIAEL 361_ IKDVT 366_ TSEDF 371_ FDKLT 376_ VEQEF 381_ MSGID 386_ TDKVN 391_ NYIED 396_ CIAQK 401_ HSLIK 406_ VLRLV 411_ CLQSV 416_ CNSGL 421_ KQKVL 426_ DYYKR 431_ EILQT 436_ YGYEH 441_ ILTLH 446_ NLEKA 451_ GLLKP 456_ QTGGR 461_ NNYPT 466_ IRKTL 471_ RLWMD 476_ DVNEQ 481_ NPTDI 486_ SYVYS 491_ GYAPL 496_ SVRLA 501_ QLLSR 506_ PGWRS 511_ IEEVL 516_ RILPG 521_ PHFEE 526_ RQPLP 531_ TGLQK 536_ KRQPG 541_ ENRVT 546_ LIFFL 551_ GGVTF 556_ AEIAA 561_ LRFLS 566_ QLEDG 571_ GTEYV 576_ IATTK 581_ LMNGT 586_ SWIEA 591_LMEKP
1: Plays a role in vesicle-mediated protein trafficking to lysosomal compartments including the endocytic membrane transport and autophagic pathways. Believed to act as a core component of the putative HOPS and CORVET endosomal tethering complexes which are proposed to be involved in the Rab5-to-Rab7 endosome conversion probably implicating MON1A/B, and via binding SNAREs and SNARE complexes to mediate tethering and docking events during SNARE-mediated membrane fusion. The HOPS complex is proposed to be recruited to Rab7 on the late endosomal membrane and to regulate late endocytic, phagocytic and autophagic traffic towards lysosomes. The CORVET complex is proposed to function as a Rab5 effector to mediate early endosome fusion probably in specific endosome subpopulations (PubMed:23351085, PubMed:24554770, PubMed:25266290, PubMed:25783203). Required for fusion of endosomes and autophagosomes with lysosomes; the function is dependent on its association with VPS16 but not VIPAS39 (PubMed:25783203). The function in autophagosome-lysosome fusion implicates STX17 but not UVRAG (PubMed:24554770)