EEF1A lysine methyltransferase 3 (EC 2.1.1.-) (Hepatocellular carcinoma-associated antigen 557a) (Methyltransferase-like protein 21B) (Protein-lysine methyltransferase METTL21B) (eEF1A-KMT3)
1_MADPG 6_ PDPES 11_ ESESV 16_ FPREV 21_ GLFAD 26_ SYSEK 31_ SQFCF 36_ CGHVL 41_ TITQN 46_ FGSRL 51_ GVAAR 56_ VWDAA 61_ LSLCN 66_ YFESQ 71_ NVDFR 76_ GKKVI 81_ ELGAG 86_ TGIVG 91_ ILAAL 96_ QGGDV 101_ TITDL 106_ PLALE 111_ QIQGN 116_ VQANV 121_ PAGGQ 126_ AQVRA 131_ LSWGI 136_ DHHVF 141_ PANYD 146_ LVLGA 151_ DIVYL 156_ EPTFP 161_ LLLGT 166_ LQHLC 171_ RPHGT 176_ IYLAS 181_ KMRKE 186_ HGTES 191_ FFQHL 196_ LPQHF 201_ QLELA 206_ QRDED 211_ ENVNI 216_ YRARH 221_REPRP
1: Protein-lysine methyltransferase that selectively mono-, di- and trimethylates 'Lys-165' of the translation elongation factors EEF1A1 and EEF1A2 in an aminoacyl-tRNA and GTP-dependent manner. EEF1A1 methylation by EEF1AKMT3 is dynamic as well as inducible by stress conditions, such as ER-stress, and plays a regulatory role on mRNA translation