Interferon-stimulated gene 20 kDa protein (EC 3.1.13.1) (Estrogen-regulated transcript 45 protein) (Promyelocytic leukemia nuclear body-associated protein ISG20)
1_MAGSR 6_ EVVAM 11_ DCEMV 16_ GLGPH 21_ RESGL 26_ ARCSL 31_ VNVHG 36_ AVLYD 41_ KFIRP 46_ EGEIT 51_ DYRTR 56_ VSGVT 61_ PQHMV 66_ GATPF 71_ AVARL 76_ EILQL 81_ LKGKL 86_ VVGHD 91_ LKHDF 96_ QALKE 101_ DMSGY 106_ TIYDT 111_ STDRL 116_ LWREA 121_ KLDHC 126_ RRVSL 131_ RVLSE 136_ RLLHK 141_ SIQNS 146_ LLGHS 151_ SVEDA 156_ RATME 161_ LYQIS 166_ QRIRA 171_ RRGLP 176_RLAVS
1: Interferon-induced antiviral exoribonuclease that acts mainly on single-stranded RNA (PubMed:11401564, PubMed:12594219, PubMed:16033969). Exhibits antiviral activity against RNA viruses including hepatitis C virus (HCV), hepatitis A virus (HAV) and yellow fever virus (YFV) (PubMed:16514659, PubMed:21036379). Inhibition of several viruses such as chikungunya virus (CHIKV) does not involve the degradation of viral RNAs, but rather the inhibition of translation of viral proteins (By similarity). Exerts a translational control over a large panel of non-self RNA substrates while sparing endogenous transcripts. This activity correlates with the protein's ability to localize in cytoplasmic processing bodies (PubMed:31600344). May also act as master regulator of over hundred interferon stimulated genes leading to viral genome translation inhibition (By similarity). May play additional roles in the maturation of snRNAs and rRNAs, and in ribosome biogenesis (PubMed:16514659)