Gene name: TMEM45B

Uniprot entry:

Q96B21

Protein names:

Transmembrane protein 45B

Protein sequence:

1_MANFK 6_ GHALP 11_ GSFFL 16_ IIGLC 21_ WSVKY 26_ PLKYF 31_ SHTRK 36_ NSPLH 41_ YYQRL 46_ EIVEA 51_ AIRTL 56_ FSVTG 61_ ILAEQ 66_ FVPDG 71_ PHLHL 76_ YHENH 81_ WIKLM 86_ NWQHS 91_ TMYLF 96_ FAVSG 101_ IVDML 106_ TYLVS 111_ HVPLG 116_ VDRLV 121_ MAVAV 126_ FMEGF 131_ LFYYH 136_ VHNRP 141_ PLDQH 146_ IHSLL 151_ LYALF 156_ GGCVS 161_ ISLEV 166_ IFRDH 171_ IVLEL 176_ FRTSL 181_ IILQG 186_ TWFWQ 191_ IGFVL 196_ FPPFG 201_ TPEWD 206_ QKDDA 211_ NLMFI 216_ TMCFC 221_ WHYLA 226_ ALSIV 231_ AVNYS 236_ LVYCL 241_ LTRMK 246_ RHGRG 251_ EIIGI 256_ QKLNS 261_ DDTYQ 266_TALLS

Protein annotations

Protein functions:

1: Plays a role in innate immunity (PubMed:35938871). Mechanistically, promotes alphaviruses RNA degradation by interacting with the viral polymerase nsP4 and the mRNA-capping enzyme nsP1 and thereby interfering with the interaction between viral RNA and nsP1 (PubMed:35938871)