Exosome complex component RRP43 (Exosome component 8) (Opa-interacting protein 2) (OIP-2) (Ribosomal RNA-processing protein 43) (p9)
1_MAAGF 6_ KTVEP 11_ LEYYR 16_ RFLKE 21_ NCRPD 26_ GRELG 31_ EFRTT 36_ TVNIG 41_ SISTA 46_ DGSAL 51_ VKLGN 56_ TTVIC 61_ GVKAE 66_ FAAPS 71_ TDAPD 76_ KGYVV 81_ PNVDL 86_ PPLCS 91_ SRFRS 96_ GPPGE 101_ EAQVA 106_ SQFIA 111_ DVIEN 116_ SQIIQ 121_ KEDLC 126_ ISPGK 131_ LVWVL 136_ YCDLI 141_ CLDYD 146_ GNILD 151_ ACTFA 156_ LLAAL 161_ KNVQL 166_ PEVTI 171_ NEETA 176_ LAEVN 181_ LKKKS 186_ YLNIR 191_ THPVA 196_ TSFAV 201_ FDDTL 206_ LIVDP 211_ TGEEE 216_ HLATG 221_ TLTIV 226_ MDEEG 231_ KLCCL 236_ HKPGG 241_ SGLTG 246_ AKLQD 251_ CMSRA 256_ VTRHK 261_ EVKKL 266_ MDEVI 271_KSMKP
1: Non-catalytic component of the RNA exosome complex which has 3'->5' exoribonuclease activity and participates in a multitude of cellular RNA processing and degradation events. In the nucleus, the RNA exosome complex is involved in proper maturation of stable RNA species such as rRNA, snRNA and snoRNA, in the elimination of RNA processing by-products and non-coding 'pervasive' transcripts, such as antisense RNA species and promoter-upstream transcripts (PROMPTs), and of mRNAs with processing defects, thereby limiting or excluding their export to the cytoplasm. The RNA exosome may be involved in Ig class switch recombination (CSR) and/or Ig variable region somatic hypermutation (SHM) by targeting AICDA deamination activity to transcribed dsDNA substrates. In the cytoplasm, the RNA exosome complex is involved in general mRNA turnover and specifically degrades inherently unstable mRNAs containing AU-rich elements (AREs) within their 3' untranslated regions, and in RNA surveillance pathways, preventing translation of aberrant mRNAs. It seems to be involved in degradation of histone mRNA. The catalytic inactive RNA exosome core complex of 9 subunits (Exo-9) is proposed to play a pivotal role in the binding and presentation of RNA for ribonucleolysis, and to serve as a scaffold for the association with catalytic subunits and accessory proteins or complexes. EXOSC8 binds to ARE-containing RNAs