Proline-rich AKT1 substrate 1 (40 kDa proline-rich AKT substrate)
1_MASGR 6_ PEELW 11_ EAVVG 16_ AAERF 21_ RARTG 26_ TELVL 31_ LTAAP 36_ PPPPR 41_ PGPCA 46_ YAAHG 51_ RGALA 56_ EAARR 61_ CLHDI 66_ ALAHR 71_ AATAA 76_ RPPAP 81_ PPAPQ 86_ PPSPT 91_ PSPPR 96_ PTLAR 101_ EDNEE 106_ DEDEP 111_ TETET 116_ SGEQL 121_ GISDN 126_ GGLFV 131_ MDEDA 136_ TLQDL 141_ PPFCE 146_ SDPES 151_ TDDGS 156_ LSEET 161_ PAGPP 166_ TCSVP 171_ PASAL 176_ PTQQY 181_ AKSLP 186_ VSVPV 191_ WGFKE 196_ KRTEA 201_ RSSDE 206_ ENGPP 211_ SSPDL 216_ DRIAA 221_ SMRAL 226_ VLREA 231_ EDTQV 236_ FGDLP 241_ RPRLN 246_ TSDFQ 251_KLKRK
1: Negative regulator of the mechanistic target of rapamycin complex 1 (mTORC1), an evolutionarily conserved central nutrient sensor that stimulates anabolic reactions and macromolecule biosynthesis to promote cellular biomass generation and growth (PubMed:17277771, PubMed:17386266, PubMed:17510057, PubMed:29236692). In absence of insulin and nutrients, AKT1S1 associates with the mTORC1 complex and directly inhibits mTORC1 activity by blocking the MTOR substrate-recruitment site (PubMed:29236692). In response to insulin and nutrients, AKT1S1 dissociates from mTORC1 (PubMed:17386266, PubMed:18372248). Its activity is dependent on its phosphorylation state and binding to 14-3-3 (PubMed:16174443, PubMed:18372248). May also play a role in nerve growth factor-mediated neuroprotection (By similarity)