Arrestin domain-containing protein 3 (TBP-2-like inducible membrane protein) (TLIMP)
1_MVLGK 6_ VKSLT 11_ ISFDC 16_ LNDSN 21_ VPVYS 26_ SGDTV 31_ SGRVN 36_ LEVTG 41_ EIRVK 46_ SLKIH 51_ ARGHA 56_ KVRWT 61_ ESRNA 66_ GSNTA 71_ YTQNY 76_ TEEVE 81_ YFNHK 86_ DILIG 91_ HERDD 96_ DNSEE 101_ GFHTI 106_ HSGRH 111_ EYAFS 116_ FELPQ 121_ TPLAT 126_ SFEGR 131_ HGSVR 136_ YWVKA 141_ ELHRP 146_ WLLPV 151_ KLKKE 156_ FTVFE 161_ HIDIN 166_ TPSLL 171_ SPQAG 176_ TKEKT 181_ LCCWF 186_ CTSGP 191_ ISLSA 196_ KIERK 201_ GYTPG 206_ ESIQI 211_ FAEIE 216_ NCSSR 221_ MVVPK 226_ AAIYQ 231_ TQAFY 236_ AKGKM 241_ KEVKQ 246_ LVANL 251_ RGESL 256_ SSGKT 261_ ETWNG 266_ KLLKI 271_ PPVSP 276_ SILDC 281_ SIIRV 286_ EYSLM 291_ VYVDI 296_ PGAMD 301_ LFLNL 306_ PLVIG 311_ TIPLH 316_ PFGSR 321_ TSSVS 326_ SQCSM 331_ NMNWL 336_ SLSLP 341_ ERPEA 346_ PPSYA 351_ EVVTE 356_ EQRRN 361_ NLAPV 366_ SACDD 371_ FERAL 376_ QGPLF 381_ AYIQE 386_ FRFLP 391_ PPLYS 396_ EIDPN 401_ PDQSA 406_DDRPS
1: Adapter protein that plays a role in regulating cell-surface expression of adrenergic receptors and probably also other G protein-coupled receptors (PubMed:20559325, PubMed:21982743, PubMed:23208550). Plays a role in NEDD4-mediated ubiquitination and endocytosis af activated ADRB2 and subsequent ADRB2 degradation (PubMed:20559325, PubMed:23208550). May recruit NEDD4 to ADRB2 (PubMed:20559325). Alternatively, may function as adapter protein that does not play a major role in recruiting NEDD4 to ADRB2, but rather plays a role in a targeting ADRB2 to endosomes (PubMed:23208550)