Repulsive guidance molecule A (RGM domain family member A)
1_MQPPR 6_ ERLVV 11_ TGRAG 16_ WMGMG 21_ RGAGR 26_ SALGF 31_ WPTLA 36_ FLLCS 41_ FPAAT 46_ SPCKI 51_ LKCNS 56_ EFWSA 61_ TSGSH 66_ APASD 71_ DTPEF 76_ CAALR 81_ SYALC 86_ TRRTA 91_ RTCRG 96_ DLAYH 101_ SAVHG 106_ IEDLM 111_ SQHNC 116_ SKDGP 121_ TSQPR 126_ LRTLP 131_ PAGDS 136_ QERSD 141_ SPEIC 146_ HYEKS 151_ FHKHS 156_ ATPNY 161_ THCGL 166_ FGDPH 171_ LRTFT 176_ DRFQT 181_ CKVQG 186_ AWPLI 191_ DNNYL 196_ NVQVT 201_ NTPVL 206_ PGSAA 211_ TATSK 216_ LTIIF 221_ KNFQE 226_ CVDQK 231_ VYQAE 236_ MDELP 241_ AAFVD 246_ GSKNG 251_ GDKHG 256_ ANSLK 261_ ITEKV 266_ SGQHV 271_ EIQAK 276_ YIGTT 281_ IVVRQ 286_ VGRYL 291_ TFAVR 296_ MPEEV 301_ VNAVE 306_ DWDSQ 311_ GLYLC 316_ LRGCP 321_ LNQQI 326_ DFQAF 331_ HTNAE 336_ GTGAR 341_ RLAAA 346_ SPAPT 351_ APETF 356_ PYETA 361_ VAKCK 366_ EKLPV 371_ EDLYY 376_ QACVF 381_ DLLTT 386_ GDVNF 391_ TLAAY 396_ YALED 401_ VKMLH 406_ SNKDK 411_ LHLYE 416_ RTRDL 421_ PGRAA 426_ AGLPL 431_ APRPL 436_ LGALV 441_PLLAL
1: Member of the repulsive guidance molecule (RGM) family that performs several functions in the developing and adult nervous system. Regulates cephalic neural tube closure, inhibits neurite outgrowth and cortical neuron branching, and the formation of mature synapses. Binding to its receptor NEO1/neogenin induces activation of RHOA-ROCK1/Rho-kinase signaling pathway through UNC5B-ARHGEF12/LARG-PTK2/FAK1 cascade, leading to collapse of the neuronal growth cone and neurite outgrowth inhibition. Furthermore, RGMA binding to NEO1/neogenin leads to HRAS inactivation by influencing HRAS-PTK2/FAK1-AKT1 pathway. It also functions as a bone morphogenetic protein (BMP) coreceptor that may signal through SMAD1, SMAD5, and SMAD8