SH3 domain-containing kinase-binding protein 1 (CD2-binding protein 3) (CD2BP3) (Cbl-interacting protein of 85 kDa) (Human Src family kinase-binding protein 1) (HSB-1)
1_MVEAI 6_ VEFDY 11_ QAQHD 16_ DELTI 21_ SVGEI 26_ ITNIR 31_ KEDGG 36_ WWEGQ 41_ INGRR 46_ GLFPD 51_ NFVRE 56_ IKKEM 61_ KKDPL 66_ TNKAP 71_ EKPLH 76_ EVPSG 81_ NSLLS 86_ SETIL 91_ RTNKR 96_ GERRR 101_ RRCQV 106_ AFSYL 111_ PQNDD 116_ ELELK 121_ VGDII 126_ EVVGE 131_ VEEGW 136_ WEGVL 141_ NGKTG 146_ MFPSN 151_ FIKEL 156_ SGESD 161_ ELGIS 166_ QDEQL 171_ SKSSL 176_ RETTG 181_ SESDG 186_ GDSSS 191_ TKSEG 196_ ANGTV 201_ ATAAI 206_ QPKKV 211_ KGVGF 216_ GDIFK 221_ DKPIK 226_ LRPRS 231_ IEVEN 236_ DFLPV 241_ EKTIG 246_ KKLPA 251_ TTATP 256_ DSSKT 261_ EMDSR 266_ TKSKD 271_ YCKVI 276_ FPYEA 281_ QNDDE 286_ LTIKE 291_ GDIVT 296_ LINKD 301_ CIDVG 306_ WWEGE 311_ LNGRR 316_ GVFPD 321_ NFVKL 326_ LPPDF 331_ EKEGN 336_ RPKKP 341_ PPPSA 346_ PVIKQ 351_ GAGTT 356_ ERKHE 361_ IKKIP 366_ PERPE 371_ MLPNR 376_ TEEKE 381_ RPERE 386_ PKLDL 391_ QKPSV 396_ PAIPP 401_ KKPRP 406_ PKTNS 411_ LSRPG 416_ ALPPR 421_ RPERP 426_ VGPLT 431_ HTRGD 436_ SPKID 441_ LAGSS 446_ LSGIL 451_ DKDLS 456_ DRSND 461_ IDLEG 466_ FDSVV 471_ SSTEK 476_ LSHPT 481_ TSRPK 486_ ATGRR 491_ PPSQS 496_ LTSSS 501_ LSSPD 506_ IFDSP 511_ SPEED 516_ KEEHI 521_ SLAHR 526_ GVDAS 531_ KKTSK 536_ TVTIS 541_ QVSDN 546_ KASLP 551_ PKPGT 556_ MAAGG 561_ GGPAP 566_ LSSAA 571_ PSPLS 576_ SSLGT 581_ AGHRA 586_ NSPSL 591_ FGTEG 596_ KPKME 601_ PAASS 606_ QAAVE 611_ ELRTQ 616_ VRELR 621_ SIIET 626_ MKDQQ 631_ KREIK 636_ QLLSE 641_ LDEEK 646_ KIRLR 651_ LQMEV 656_NDIKK
1: Adapter protein involved in regulating diverse signal transduction pathways. Involved in the regulation of endocytosis and lysosomal degradation of ligand-induced receptor tyrosine kinases, including EGFR and MET/hepatocyte growth factor receptor, through an association with CBL and endophilins. The association with CBL, and thus the receptor internalization, may be inhibited by an interaction with PDCD6IP and/or SPRY2. Involved in regulation of ligand-dependent endocytosis of the IgE receptor. Attenuates phosphatidylinositol 3-kinase activity by interaction with its regulatory subunit (By similarity). May be involved in regulation of cell adhesion; promotes the interaction between TTK2B and PDCD6IP. May be involved in the regulation of cellular stress response via the MAPK pathways through its interaction with MAP3K4. Is involved in modulation of tumor necrosis factor mediated apoptosis. Plays a role in the regulation of cell morphology and cytoskeletal organization. Required in the control of cell shape and migration. Has an essential role in the stimulation of B cell activation (PubMed:29636373)