Cyclic AMP-responsive element-binding protein 3-like protein 1 (cAMP-responsive element-binding protein 3-like protein 1) (Old astrocyte specifically-induced substance) (OASIS) [Cleaved into: Processed cyclic AMP-responsive element-binding protein 3-like protein 1]
1_MDAVL 6_ EPFPA 11_ DRLFP 16_ GSSFL 21_ DLGDL 26_ NESDF 31_ LNNAH 36_ FPEHL 41_ DHFTE 46_ NMEDF 51_ SNDLF 56_ SSFFD 61_ DPVLD 66_ EKSPL 71_ LDMEL 76_ DSPTP 81_ GIQAE 86_ HSYSL 91_ SGDSA 96_ PQSPL 101_ VPIKM 106_ EDTTQ 111_ DAEHG 116_ AWALG 121_ HKLCS 126_ IMVKQ 131_ EQSPE 136_ LPVDP 141_ LAAPS 146_ AMAAA 151_ AAMAT 156_ TPLLG 161_ LSPLS 166_ RLPIP 171_ HQAPG 176_ EMTQL 181_ PVIKA 186_ EPLEV 191_ NQFLK 196_ VTPED 201_ LVQMP 206_ PTPPS 211_ SHGSD 216_ SDGSQ 221_ SPRSL 226_ PPSSP 231_ VRPMA 236_ RSSTA 241_ ISTSP 246_ LLTAP 251_ HKLQG 256_ TSGPL 261_ LLTEE 266_ EKRTL 271_ IAEGY 276_ PIPTK 281_ LPLTK 286_ AEEKA 291_ LKRVR 296_ RKIKN 301_ KISAQ 306_ ESRRK 311_ KKEYV 316_ ECLEK 321_ KVETF 326_ TSENN 331_ ELWKK 336_ VETLE 341_ NANRT 346_ LLQQL 351_ QKLQT 356_ LVTNK 361_ ISRPY 366_ KMAAT 371_ QTGTC 376_ LMVAA 381_ LCFVL 386_ VLGSL 391_ VPCLP 396_ EFSSG 401_ SQTVK 406_ EDPLA 411_ ADGVY 416_ TASQM 421_ PSRSL 426_ LFYDD 431_ GAGLW 436_ EDGRS 441_ TLLPM 446_ EPPDG 451_ WEINP 456_ GGPAE 461_ QRPRD 466_ HLQHD 471_ HLDST 476_ HETTK 481_ YLSEA 486_ WPKDG 491_ GNGTS 496_ PDFSH 501_ SKEWF 506_ HDRDL 511_GPNTT
1: Precursor of the transcription factor form (Processed cyclic AMP-responsive element-binding protein 3-like protein 1), which is embedded in the endoplasmic reticulum membrane with N-terminal DNA-binding and transcription activation domains oriented toward the cytosolic face of the membrane (PubMed:12054625, PubMed:16417584, PubMed:25310401). In response to ER stress or DNA damage, transported to the Golgi, where it is cleaved in a site-specific manner by resident proteases S1P/MBTPS1 and S2P/MBTPS2. The released N-terminal cytosolic domain is translocated to the nucleus where it activates transcription of specific target genes involved in the cell-cycle progression inhibition (PubMed:12054625, PubMed:21767813, PubMed:25310401)
2: Transcription factor involved in cell type specific DNA damage and unfolded protein response (UPR). Binds the DNA consensus sequence 5'-GTGXGCXGC-3' (PubMed:21767813). Plays a critical role in bone formation through the transcription of COL1A1, and possibly COL1A2, and the secretion of bone matrix proteins. Directly binds to the UPR element (UPRE)-like sequence in an osteoblast-specific COL1A1 promoter region and induces its transcription. Does not regulate COL1A1 in other tissues, such as skin (By similarity). Required to protect astrocytes from ER stress-induced cell death. In astrocytes, binds to the cAMP response element (CRE) of the BiP/HSPA5 promoter and participate in its transcriptional activation (By similarity). In astrocytes and osteoblasts, upon DNA damage, inhibits cell-cycle progression after G2/M phase by binding to promoters and activating transcription of genes encoding cell-cycle inhibitors, such as p21/CDKN1A (By similarity). Required for TGFB1 to activate genes involved in the assembly of collagen extracellular matrix (PubMed:25310401)
3: (Microbial infection) May play a role in limiting virus spread by inhibiting proliferation of virus-infected cells. Upon infection with diverse DNA and RNA viruses, inhibits cell-cycle progression by binding to promoters and activating transcription of genes encoding cell-cycle inhibitors, such as p21/CDKN1A (PubMed:21767813)