Solute carrier organic anion transporter family member 4A1 (OATP4A1) (Colon organic anion transporter) (Organic anion transporter polypeptide-related protein 1) (OATP-RP1) (OATPRP1) (POAT) (Organic anion-transporting polypeptide E) (OATP-E) (Sodium-independent organic anion transporter E) (Solute carrier family 21 member 12)
1_MPLHQ 6_ LGDKP 11_ LTFPS 16_ PNSAM 21_ ENGLD 26_ HTPPS 31_ RRASP 36_ GTPLS 41_ PGSLR 46_ SAAHS 51_ PLDTS 56_ KQPLC 61_ QLWAE 66_ KHGAR 71_ GTHEV 76_ RYVSA 81_ GQSVA 86_ CGWWA 91_ FAPPC 96_ LQVLN 101_ TPKGI 106_ LFFLC 111_ AAAFL 116_ QGMTV 121_ NGFIN 126_ TVITS 131_ LERRY 136_ DLHSY 141_ QSGLI 146_ ASSYD 151_ IAACL 156_ CLTFV 161_ SYFGG 166_ SGHKP 171_ RWLGW 176_ GVLLM 181_ GTGSL 186_ VFALP 191_ HFTAG 196_ RYEVE 201_ LDAGV 206_ RTCPA 211_ NPGAV 216_ CADST 221_ SGLSR 226_ YQLVF 231_ MLGQF 236_ LHGVG 241_ ATPLY 246_ TLGVT 251_ YLDEN 256_ VKSSC 261_ SPVYI 266_ AIFYT 271_ AAILG 276_ PAAGY 281_ LIGGA 286_ LLNIY 291_ TEMGR 296_ RTELT 301_ TESPL 306_ WVGAW 311_ WVGFL 316_ GSGAA 321_ AFFTA 326_ VPILG 331_ YPRQL 336_ PGSQR 341_ YAVMR 346_ AAEMH 351_ QLKDS 356_ SRGEA 361_ SNPDF 366_ GKTIR 371_ DLPLS 376_ IWLLL 381_ KNPTF 386_ ILLCL 391_ AGATE 396_ ATLIT 401_ GMSTF 406_ SPKFL 411_ ESQFS 416_ LSASE 421_ AATLF 426_ GYLVV 431_ PAGGG 436_ GTFLG 441_ GFFVN 446_ KLRLR 451_ GSAVI 456_ KFCLF 461_ CTVVS 466_ LLGIL 471_ VFSLH 476_ CPSVP 481_ MAGVT 486_ ASYGG 491_ SLLPE 496_ GHLNL 501_ TAPCN 506_ AACSC 511_ QPEHY 516_ SPVCG 521_ SDGLM 526_ YFSLC 531_ HAGCP 536_ AATET 541_ NVDGQ 546_ KVYRD 551_ CSCIP 556_ QNLSS 561_ GFGHA 566_ TAGKC 571_ TSTCQ 576_ RKPLL 581_ LVFIF 586_ VVIFF 591_ TFLSS 596_ IPALT 601_ ATLRC 606_ VRDPQ 611_ RSFAL 616_ GIQWI 621_ VVRIL 626_ GGIPG 631_ PIAFG 636_ WVIDK 641_ ACLLW 646_ QDQCG 651_ QQGSC 656_ LVYQN 661_ SAMSR 666_ YILIM 671_ GLLYK 676_ VLGVL 681_ FFAIA 686_ CFLYK 691_ PLSES 696_ SDGLE 701_ TCLPS 706_ QSSAP 711_ DSATD 716_SQLQS
1: Organic anion antiporter with apparent broad substrate specificity. Recognizes various substrates including thyroid hormones 3,3',5-triiodo-L-thyronine (T3), L-thyroxine (T4) and 3,3',5'-triiodo-L-thyronine (rT3), conjugated steroids such as estrone 3-sulfate and estradiol 17-beta glucuronide, bile acids such as taurocholate and prostanoids such as prostaglandin E2, likely operating in a tissue-specific manner (PubMed:10873595, PubMed:19129463, PubMed:30343886). May be involved in uptake of metabolites from the circulation into organs such as kidney, liver or placenta. Possibly drives the selective transport of thyroid hormones and estrogens coupled to an outward glutamate gradient across the microvillous membrane of the placenta (PubMed:30343886). The transport mechanism, its electrogenicity and potential tissue-specific counterions remain to be elucidated (Probable)