SPRY domain-containing SOCS box protein 1 (SSB-1)
1_MGQKV 6_ TGGIK 11_ TVDMR 16_ DPTYR 21_ PLKQE 26_ LQGLD 31_ YCKPT 36_ RLDLL 41_ LDMPP 46_ VSYDV 51_ QLLHS 56_ WNNND 61_ RSLNV 66_ FVKED 71_ DKLIF 76_ HRHPV 81_ AQSTD 86_ AIRGK 91_ VGYTR 96_ GLHVW 101_ QITWA 106_ MRQRG 111_ THAVV 116_ GVATA 121_ DAPLH 126_ SVGYT 131_ TLVGN 136_ NHESW 141_ GWDLG 146_ RNRLY 151_ HDGKN 156_ QPSKT 161_ YPAFL 166_ EPDET 171_ FIVPD 176_ SFLVA 181_ LDMDD 186_ GTLSF 191_ IVDGQ 196_ YMGVA 201_ FRGLK 206_ GKKLY 211_ PVVSA 216_ VWGHC 221_ EIRMR 226_ YLNGL 231_ DPEPL 236_ PLMDL 241_ CRRSV 246_ RLALG 251_ RERLG 256_ EIHTL 261_ PLPAS 266_LKAYL
1: Substrate recognition component of a SCF-like ECS (Elongin BC-CUL2/5-SOCS-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins (PubMed:15601820, PubMed:21199876). Negatively regulates nitric oxide (NO) production and limits cellular toxicity in activated macrophages by mediating the ubiquitination and proteasomal degradation of NOS2 (PubMed:21199876). Acts as a bridge which links NOS2 with the ECS E3 ubiquitin ligase complex components ELOC and CUL5 (PubMed:21199876)