Transmembrane and immunoglobulin domain-containing protein 2 (CD28 homolog) (Immunoglobulin and proline-rich receptor 1) (IGPR-1)
1_MGSPG 6_ MVLGL 11_ LVQIW 16_ ALQEA 21_ SSLSV 26_ QQGPN 31_ LLQVR 36_ QGSQA 41_ TLVCQ 46_ VDQAT 51_ AWERL 56_ RVKWT 61_ KDGAI 66_ LCQPY 71_ ITNGS 76_ LSLGV 81_ CGPQG 86_ RLSWQ 91_ APSHL 96_ TLQLD 101_ PVSLN 106_ HSGAY 111_ VCWAA 116_ VEIPE 121_ LEEAE 126_ GNITR 131_ LFVDP 136_ DDPTQ 141_ NRNRI 146_ ASFPG 151_ FLFVL 156_ LGVGS 161_ MGVAA 166_ IVWGA 171_ WFWGR 176_ RSCQQ 181_ RDSGN 186_ SPGNA 191_ FYSNV 196_ LYRPR 201_ GAPKK 206_ SEDCS 211_ GEGKD 216_ QRGQS 221_ IYSTS 226_ FPQPA 231_ PRQPH 236_ LASRP 241_ CPSPR 246_ PCPSP 251_ RPGHP 256_ VSMVR 261_ VSPRP 266_ SPTQQ 271_ PRPKG 276_FPKVG
1: Plays a role in cell-cell interaction, cell migration, and angiogenesis. Through interaction with HHLA2, costimulates T-cells in the context of TCR-mediated activation. Enhances T-cell proliferation and cytokine production via an AKT-dependent signaling cascade