E3 ubiquitin-protein ligase RNF25 (EC 2.3.2.27) (RING finger protein 25) (RING-type E3 ubiquitin transferase RNF25)
1_MAASA 6_ SAAAG 11_ EEDWV 16_ LPSEV 21_ EVLES 26_ IYLDE 31_ LQVIK 36_ GNGRT 41_ SPWEI 46_ YITLH 51_ PATAE 56_ DQDSQ 61_ YVCFT 66_ LVLQV 71_ PAEYP 76_ HEVPQ 81_ ISIRN 86_ PRGLS 91_ DEQIH 96_ TILQV 101_ LGHVA 106_ KAGLG 111_ TAMLY 116_ ELIEK 121_ GKEIL 126_ TDNNI 131_ PHGQC 136_ VICLY 141_ GFQEK 146_ EAFTK 151_ TPCYH 156_ YFHCH 161_ CLARY 166_ IQHME 171_ QELKA 176_ QGQEQ 181_ EQERQ 186_ HATTK 191_ QKAVG 196_ VQCPV 201_ CREPL 206_ VYDLA 211_ SLKAA 216_ PEPQQ 221_ PMELY 226_ QPSAE 231_ SLRQQ 236_ EERKR 241_ LYQRQ 246_ QERGG 251_ IIDLE 256_ AERNR 261_ YFISL 266_ QQPPA 271_ PAEPE 276_ SAVDV 281_ SKGSQ 286_ PPSTL 291_ AAELS 296_ TSPAV 301_ QSTLP 306_ PPLPV 311_ ATQHI 316_ CEKIP 321_ GTRSN 326_ QQRLG 331_ ETQKA 336_ MLDPP 341_ KPSRG 346_ PWRQP 351_ ERRHP 356_ KGGEC 361_ HAPKG 366_ TRDTQ 371_ ELPPP 376_ EGPLK 381_ EPMDL 386_ KPEPH 391_ SQGVE 396_ GPPQE 401_ KGPGS 406_ WQGPP 411_ PRRTR 416_ DCVRW 421_ ERSKG 426_ RTPGS 431_ SYPRL 436_ PRGQG 441_ AYRPG 446_ TRRES 451_LGLES
1: E3 ubiquitin-protein ligase that plays a key role in the RNF14-RNF25 translation quality control pathway, a pathway that takes place when a ribosome has stalled during translation, and which promotes ubiquitination and degradation of translation factors on stalled ribosomes (PubMed:36638793, PubMed:37651229, PubMed:37951216). Catalyzes ubiquitination of RPS27A in response to ribosome collisions, promoting activation of RNF14 (PubMed:36638793). RNF25 catalyzes ubiquitination of other ribosomal proteins on stalled ribosomes, such as RPL0, RPL1, RPL12, RPS13 and RPS17 (PubMed:36638793). Also involved in ubiquitination and degradation of stalled ETF1/eRF1 (PubMed:36638793, PubMed:37651229). Independently of its function in the response to stalled ribosomes, mediates ubiquitination and subsequent proteasomal degradation of NKD2 (By similarity). May also stimulate transcription mediated by NF-kappa-B via its interaction with RELA/p65 (PubMed:12748188)