Gamma-secretase subunit APH-1A (APH-1a) (Aph-1alpha) (Presenilin-stabilization factor)
1_MGAAV 6_ FFGCT 11_ FVAFG 16_ PAFAL 21_ FLITV 26_ AGDPL 31_ RVIIL 36_ VAGAF 41_ FWLVS 46_ LLLAS 51_ VVWFI 56_ LVHVT 61_ DRSDA 66_ RLQYG 71_ LLIFG 76_ AAVSV 81_ LLQEV 86_ FRFAY 91_ YKLLK 96_ KADEG 101_ LASLS 106_ EDGRS 111_ PISIR 116_ QMAYV 121_ SGLSF 126_ GIISG 131_ VFSVI 136_ NILAD 141_ ALGPG 146_ VVGIH 151_ GDSPY 156_ YFLTS 161_ AFLTA 166_ AIILL 171_ HTFWG 176_ VVFFD 181_ ACERR 186_ RYWAL 191_ GLVVG 196_ SHLLT 201_ SGLTF 206_ LNPWY 211_ EASLL 216_ PIYAV 221_ TVSMG 226_ LWAFI 231_ TAGGS 236_ LRSIQ 241_ RSLLC 246_ RRQED 251_ SRVMV 256_YSALR
1: Non-catalytic subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors and APP (amyloid-beta precursor protein) (PubMed:12297508, PubMed:12522139, PubMed:12679784, PubMed:12763021, PubMed:25043039, PubMed:26280335, PubMed:30598546, PubMed:30630874). Required for normal gamma-secretase assembly (PubMed:12471034, PubMed:12522139, PubMed:12763021, PubMed:19369254). The gamma-secretase complex plays a role in Notch and Wnt signaling cascades and regulation of downstream processes via its role in processing key regulatory proteins, and by regulating cytosolic CTNNB1 levels (Probable)