Axin interactor, dorsalization-associated protein (Axin interaction partner and dorsalization antagonist)
1_MSEVT 6_ RSLLQ 11_ RWGAS 16_ FRRGA 21_ DFDSW 26_ GQLVE 31_ AIDEY 36_ QILAR 41_ HLQKE 46_ AQAQH 51_ NNSEF 56_ TEEQK 61_ KTIGK 66_ IATCL 71_ ELRSA 76_ ALQST 81_ QSQEE 86_ FKLED 91_ LKKLE 96_ PILKN 101_ ILTYN 106_ KEFPF 111_ DVQPV 116_ PLRRI 121_ LAPGE 126_ EENLE 131_ FEEDE 136_ EEGGA 141_ GAGSP 146_ DSFPA 151_ RVPGT 156_ LLPRL 161_ PSEPG 166_ MTLLT 171_ IRIEK 176_ IGLKD 181_ AGQCI 186_ DPYIT 191_ VSVKD 196_ LNGID 201_ LTPVQ 206_ DTPVA 211_ SRKED 216_ TYVHF 221_ NVDIE 226_ LQKHV 231_ EKLTK 236_ GAAIF 241_ FEFKH 246_ YKPKK 251_ RFTST 256_ KCFAF 261_ MEMDE 266_ IKPGP 271_ IVIEL 276_ YKKPT 281_ DFKRK 286_ KLQLL 291_ TKKPL 296_ YLHLH 301_QTLHK
1: Acts as a ventralizing factor during embryogenesis. Inhibits axin-mediated JNK activation by binding axin and disrupting axin homodimerization. This in turn antagonizes a Wnt/beta-catenin-independent dorsalization pathway activated by AXIN/JNK-signaling (By similarity)