PIN2/TERF1-interacting telomerase inhibitor 1 (Liver-related putative tumor suppressor) (Pin2-interacting protein X1) (Protein 67-11-3) (TRF1-interacting protein 1)
1_MSMLA 6_ ERRRK 11_ QKWAV 16_ DPQNT 21_ AWSND 26_ DSKFG 31_ QRMLE 36_ KMGWS 41_ KGKGL 46_ GAQEQ 51_ GATDH 56_ IKVQV 61_ KNNHL 66_ GLGAT 71_ INNED 76_ NWIAH 81_ QDDFN 86_ QLLAE 91_ LNTCH 96_ GQETT 101_ DSSDK 106_ KEKKS 111_ FSLEE 116_ KSKIS 121_ KNRVH 126_ YMKFT 131_ KGKDL 136_ SSRSK 141_ TDLDC 146_ IFGKR 151_ QSKKT 156_ PEGDA 161_ SPSTP 166_ EENET 171_ TTTSA 176_ FTIQE 181_ YFAKR 186_ MAALK 191_ NKPQV 196_ PVPGS 201_ DISET 206_ QVERK 211_ RGKKR 216_ NKEAT 221_ GKDVE 226_ SYLQP 231_ KAKRH 236_ TEGKP 241_ ERAEA 246_ QERVA 251_ KKKSA 256_ PAEEQ 261_ LRGPC 266_ WDQSS 271_ KASAQ 276_ DAGDH 281_ VQPPE 286_ GRDFT 291_ LKPKK 296_ RRGKK 301_ KLQKP 306_ VEIAE 311_ DATLE 316_ ETLVK 321_KKKKK
1: Microtubule-binding protein essential for faithful chromosome segregation. Mediates TRF1 and TERT accumulation in nucleolus and enhances TRF1 binding to telomeres. Inhibits telomerase activity. May inhibit cell proliferation and act as tumor suppressor