Ankyrin repeat domain-containing protein 9
1_MPWDA 6_ RRPGG 11_ GADGG 16_ PEASG 21_ AARSR 26_ AQKQC 31_ RKSSF 36_ AFYQA 41_ VRDLL 46_ PVWLL 51_ EDMRA 56_ SEAFH 61_ WDERG 66_ RAAAY 71_ SPSEA 76_ LLYAL 81_ VHDHQ 86_ AYAHY 91_ LLATF 96_ PRRAL 101_ APPSA 106_ GFRCC 111_ AAPGP 116_ HVALA 121_ VRYNR 126_ VGILR 131_ RILRT 136_ LRDFP 141_ AEERA 146_ RVLDR 151_ RGCSR 156_ VEGGG 161_ TSLHV 166_ ACELA 171_ RPECL 176_ FLLLG 181_ HGASP 186_ GLRDG 191_ GGLTP 196_ LELLL 201_ RQLGR 206_ DAGAT 211_ PSAAG 216_ APASA 221_ PGEPR 226_ QRRLL 231_ LLDLL 236_ ALYTP 241_ VGAAG 246_ SARQE 251_ LLGDR 256_ PRWQR 261_ LLGED 266_ KFQWL 271_ AGLAP 276_ PSLFA 281_ RAMQV 286_ LVTAI 291_ SPGRF 296_ PEALD 301_ ELPLP 306_ PFLQP 311_LDLTG
1: Substrate receptor subunit of a cullin-RING superfamily E3 ligase complex (CUL5-based E3 ubiquitin ligase complex) which mediates the ubiquitination and subsequent proteasomal degradation of target proteins (PubMed:30293565). Depending of the metabolic state of the cell, promotes the proteasomal degradation of IMPDH2, the rate-limiting enzyme in GTP biosynthesis or protects IMPDH2 by stabilizing IMPDH2 filaments assembly (PubMed:30293565, PubMed:31337707). Implicated in different cellular processes, like copper homeostasis and cell proliferation (PubMed:24522796, PubMed:30293565)